ArticleLight, science & applications2021
Lipid droplets as endogenous intracellular microlenses.
Article in Light, science & applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Virtual Overlay Staining With Plasmonic Oligomer Metasurface.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Two-Photon 3D Printing of Functional Microstructures Inside Living Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Optical Tweezers in Emulsion Research: Principles, Advances, and Prospects.Langmuir : the ACS journal of surfaces and colloids · 2026Review
- Advanced multimodal imaging: FLIM, PLIM, and FluoRaman enabled by novel diarylacetylene probes.The Analyst · 2026Article
- Light force-powered cellular medical micromachines.Frontiers in bioengineering and biotechnology · 2026Review
- An Opto-Bio-Hydrodynamic Platform for Instructing Cardiac Left-Right Asymmetry Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Polarization-Sensitive Holotomography for Multidimensional Label-Free Imaging and Characterization of Lipid Droplets in Cancer Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- BlurryScope enables compact, cost-effective scanning microscopy for HER2 scoring using deep learning on blurry images.NPJ digital medicine · 2025Article
- Holotomographic microscopy reveals label-free quantitative dynamics of endothelial cells during endothelialization.European journal of cell biology · 2025Article
- Single-molecule manipulation and detection by WGM-coupled photonic nanojets.Discover nano · 2025Article
- Metasurface-Coated Liquid Microlens for Super Resolution Imaging.Micromachines · 2024Article
- Emerging Fluorescent Nanoparticles for Non-Invasive Bioimaging.Molecules (Basel, Switzerland) · 2024Review
- Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023Article
- Noninvasive morpho-molecular imaging reveals early therapy-induced senescence in human cancer cells.Science advances · 2023Article
- Lipid droplets: a cellular organelle vital in cancer cells.Cell death discovery · 2023Review
- Finding intracellular lipid droplets from the single-cell biolens' signature in a holographic flow-cytometry assay.Biomedical optics express · 2022Article
- Controllable Formation and Real-Time Characterization of Single Microdroplets Using Optical Tweezers.Micromachines · 2022Article
- Optically controlled coalescence and splitting of femtoliter/picoliter droplets for microreactors.RSC advances · 2022Article
- Optical-force-controlled red-blood-cell microlenses for subwavelength trapping and imaging.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
Using a single biological element as a photonic component with well-defined features has become a new intriguing paradigm in biophotonics. Here we show that endogenous lipid droplets in the mature adipose cells can behave as fully biocompatible microlenses to strengthen the ability of microscopic imaging as well as detecting intra- and extracellular signals. By the assistance of biolenses made of the lipid droplets, enhanced fluorescence imaging of cytoskeleton, lysosomes, and adenoviruses has been achieved. At the same time, we demonstrated that the required excitation power can be reduced by up to 73%. The lipidic microlenses are finely manipulated by optical tweezers in order to address targets and perform their real-time imaging inside the cells. An efficient detecting of fluorescence signal of cancer cells in extracellular fluid was accomplished due to the focusing effect of incident light by the lipid droplets. The lipid droplets acting as endogenous intracellular microlenses open the intriguing route for a multifunctional biocompatible optics tool for biosensing, endoscopic imaging, and single-cell diagnosis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.