ArticleBMJ open2021
Causes of infective endocarditis in the Western Cape, South Africa: a prospective cohort study using a set protocol for organism detection and central decision making by an endocarditis team.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Genomic comparison of Staphylococcus aureus isolates from patients with bacteraemia and infective endocarditis at public hospitals in Gauteng, South Africa.World journal of microbiology & biotechnology · 2026Article
- A case series of confirmedEuropean heart journal. Case reports · 2026Article
- Article
- Including louse-borneLancet regional health. Americas · 2025Article
- Infective endocarditis: it takes a team.European heart journal · 2025Review
- Favourable outcome ofSouthern African journal of infectious diseases · 2025Article
- The Surgical Outcome of Infective Endocarditis in South Africa over 10 Years: A Retrospective Review.Journal of clinical medicine · 2024Article
- Hidden Burden ofOpen forum infectious diseases · 2024Review
- Early surgery determines prognosis in patients with infective endocarditis: outcome in patients managed by an Endocarditis Team-a prospective cohort study.Cardiovascular diagnosis and therapy · 2022Article
- Modified Duke/European Society of Cardiology 2015 clinical criteria for infective endocarditis: time for an update?Open heart · 2022Article
- Clinical Characteristics and Risk Factors for in-Hospital Mortality in 240 Cases of Infective Endocarditis in a Tertiary Hospital in China: A Retrospective Study.Infection and drug resistance · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood culture negative infective endocarditis (BCNIE) poses both a diagnostic and therapeutic challenge. High rates of BCNIE reported in South Africa have been attributed to antibiotic use prior to blood culture sampling.
objectivesTo assess the impact of a systematic approach to organism detection and identify the causes of infective endocarditis (IE), in particular causes of BCNIE.
designProspective cohort study.
methodsThe Tygerberg Endocarditis Cohort study prospectively enrolled patients with IE between November 2019 and February 2021. A set protocol for organism detection with management of patients by an endocarditis team was employed. This prospective cohort was compared with a retrospective cohort of patients with IE admitted between January 2017 and December 2018.
resultsOne hundred and forty patients with IE were included, with 75 and 65 patients in the retrospective and prospective cohorts, respectively. Baseline demographic characteristics were similar with a mean age of 39.6 years and male predominance (male sex=67.1%). The rate of BCNIE was lower in the prospective group (28/65 or 43.1%) compared with the retrospective group (47/75 or 62.7%; p=0.039). The BCNIE in-hospital mortality rate in the retrospective cohort was 23.4% compared with 14.2% in the prospective cohort (p=0.35). A cause was identified (including non-culture techniques) in 86.2% of patients in the prospective cohort, with
conclusionThe introduction of a set protocol for organism detection, managed by an endocarditis team, has identified
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