Evidence map›Paper›PMID 34872978›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Divergent Genetic Regulation of Nitric Oxide Production between C57BL/6J and Wild-Derived PWD/PhJ Mice Controls Postactivation Mitochondrial Metabolism, Cell Survival, and Bacterial Resistance in Dendritic Cells.

Julia P Snyder, Soyeon K Gullickson, Roxana Del Rio-Guerra, Andrea Sweezy, Bay Vagher, Tyler C Hogan, Karolyn G Lahue, Julie A Reisz, Angelo D'Alessandro, Dimitry N Krementsov and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Julia P SnyderCell, Molecular, and Biomedical Sciences Program, University of Vermont, Burlington, VT.
Soyeon K GullicksonCell, Molecular, and Biomedical Sciences Program, University of Vermont, Burlington, VT.ORCID 0000-0002-0759-6332
Roxana Del Rio-GuerraFlow Cytometry and Cell Sorting Facility, Larner College of Medicine, University of Vermont, Burlington, VT.
Andrea SweezyUndergraduate Student Research, University of Vermont, Burlington, VT; and.
Bay VagherCell, Molecular, and Biomedical Sciences Program, University of Vermont, Burlington, VT.ORCID 0000-0003-3822-116X
Tyler C HoganDepartment of Biomedical and Health Sciences, College of Nursing and Health Sciences, University of Vermont, Burlington, VT.ORCID 0000-0003-4718-0726
Karolyn G LahueDepartment of Biomedical and Health Sciences, College of Nursing and Health Sciences, University of Vermont, Burlington, VT.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado, Aurora, CO.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado, Aurora, CO.ORCID 0000-0002-2258-6490
Dimitry N KrementsovCell, Molecular, and Biomedical Sciences Program, University of Vermont, Burlington, VT.ORCID 0000-0003-2709-7466
Eyal AmielCell, Molecular, and Biomedical Sciences Program, University of Vermont, Burlington, VT; Eyal.Amiel@med.uvm.edu.
University of Vermont · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Vermont Immunobioloigy/ Infectious Diseases CenterP20GM103496 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2012 to 2015
$8.7M
Vermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8M
Vermont Immunology/Infectious Diseases Training GrantT32AI055402 · NIAID · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI GARY E WARD · 2005 to 2026
$2.7M
Interactions Between Host Genetics and the Gut Microbiome in CNS AutoimmunityR01NS097596 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KREMENTSOV, DIMITRY N · 2017 to 2021
$1.7M
Next generation systems analysis of pathogenetic mechanisms underlying CNS autoimmunityR21AI145306 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KREMENTSOV, DIMITRY N · 2019 to 2020
$429k
The Role of Glycogen Metabolism in Supporting Dendritic Cell Immune FunctionR21AI135385 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI AMIEL, EYAL · 2018 to 2019
$422k
Acquisition of a new Flow CytometerS10OD026843 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOYSON, JONATHAN E · 2019 to 2019
$204k
NIAID NIH HHS R21 AI135385NIAID NIH HHS R21 AI145306NIAID NIH HHS T32 AI055402NIGMS NIH HHS P20 GM103496NIGMS NIH HHS P30 GM118228NIH HHS S10 OD026843NINDS NIH HHS R01 NS097596
6 · The paper itself

Abstract

Dendritic cell (DC) activation is characterized by sustained commitment to glycolysis that is a requirement for survival in DC subsets that express inducible NO synthase (

Indexed as

AllelesAnimalsAnimals, WildCells, CulturedCell SurvivalDendritic CellsDisease Models, AnimalDisease ResistanceGenetic BackgroundHumansLipopolysaccharidesListeria monocytogenesListeriosisMiceMice, Inbred C57BLMitochondriaLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IINos2 protein, mouse

Identifiers

PMID34872978
PMCPMC8702458
OpenAlexW4200543275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.