Evidence map›Paper›PMID 34872929›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing.

Ekin Su Akdemir, Junsung Woo, Navish A Bosquez Huerta, Brittney Lozzi, Andrew K Groves, Akdes Serin Harmanci, Benjamin Deneen

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Sculpting Astrocyte Diversity through Circuits and Transcription.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ekin Su AkdemirProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030.
Junsung WooCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030.
Navish A Bosquez HuertaProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030.ORCID 0000-0003-3154-1574
Brittney LozziCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030.
Andrew K GrovesProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030.ORCID 0000-0002-0784-7998
Akdes Serin HarmanciDepartment of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030.
Benjamin DeneenProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030 deneen@bcm.edu.
Baylor College of Medicine · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Initiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4M
Training In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9M
Enhancing Atoh1 function in hair cell regenerationR01DC014832 · NIDCD · WASHINGTON UNIVERSITY · PI Gabriel Corfas, Andrew K Groves · 2016 to 2026
$6.7M
Transcriptional regulation of gliogenesis in the CNSR01NS071153 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN · 2010 to 2022
$5.0M
Defining Roles for Astrocyte Subpopulations in the Aging BrainR01AG071687 · NIA · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN · 2021 to 2025
$2.0M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NHLBI NIH HHS T32 HL092332NIA NIH HHS R01 AG071687NIDCD NIH HHS R01 DC014832NIGMS NIH HHS R25 GM056929NINDS NIH HHS R01 NS071153
6 · The paper itself

Abstract

Astrocytes are the most abundant glial cell in the brain and perform a wide range of tasks that support neuronal function and circuit activities. There is emerging evidence that astrocytes exhibit molecular and cellular heterogeneity; however, whether distinct subpopulations perform these diverse roles remains poorly defined. Here we show that the Lunatic Fringe-GFP (Lfng-GFP) bacteria artificial chromosome mouse line from both sexes specifically labels astrocyte populations within lamina III and IV of the dorsal spinal cord. Transcriptional profiling of Lfng-GFP

Indexed as

AnimalsAstrocytesFemaleGlycosyltransferasesGreen Fluorescent ProteinsMaleMiceMice, Inbred C57BLMice, TransgenicPerceptionSpinal CordGlycosyltransferasesGreen Fluorescent ProteinsLfng protein, mouseastrocytecircuit activitiesgliasensory processingspinal cord

Identifiers

PMID34872929
PMCPMC8805626
OpenAlexW4200009196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.