Evidence map›Paper›PMID 34872587›Full record

ArticleEnvironmental health : a global access science source2021

The influence of dietary intake of omega-3 polyunsaturated fatty acids on the association between short-term exposure to ambient nitrogen dioxide and respiratory and cardiovascular outcomes among healthy adults.

Hao Chen, Siqi Zhang, Wan Shen, Claudia Salazar, Alexandra Schneider, Lauren Wyatt, Ana G Rappold, David Diaz-Sanchez, Robert B Devlin, James M Samet and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Environmental health : a global access science source, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02921048 (Effects of Omega-3 Fatty Acids in Ambient Air Pollution Exposure in Healthy Adults), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02921048 completednot on this map

Effects of Omega-3 Fatty Acids in Ambient Air Pollution Exposure in Healthy Adults

TypeobservationalSponsorU.S. EPA Human Studies FacilityRan2016 to 2019Enrolled62ConditionsHealth Effects of Ambient Air PollutionArmsomega-3 fatty acids
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Prenatal Nitrogen Oxide (NOEnvironmental science & technology · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Hao ChenOak Ridge Institute for Science and Education, 100 ORAU Way, 37830, Oak Ridge, TN, USA. chen.hao@epa.gov.
Siqi ZhangInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Wan ShenOak Ridge Institute for Science and Education, 100 ORAU Way, 37830, Oak Ridge, TN, USA.
Claudia SalazarPublic Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 104 Mason Farm Rd, 27514, Chapel Hill, NC, USA.
Alexandra SchneiderInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Lauren WyattPublic Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 104 Mason Farm Rd, 27514, Chapel Hill, NC, USA.
Ana G RappoldPublic Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 104 Mason Farm Rd, 27514, Chapel Hill, NC, USA.
David Diaz-SanchezPublic Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 104 Mason Farm Rd, 27514, Chapel Hill, NC, USA.
Robert B DevlinPublic Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 104 Mason Farm Rd, 27514, Chapel Hill, NC, USA.
James M SametPublic Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 104 Mason Farm Rd, 27514, Chapel Hill, NC, USA.
Haiyan TongPublic Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 104 Mason Farm Rd, 27514, Chapel Hill, NC, USA. tong.haiyan@epa.gov.ORCID 0000-0001-9050-5739
Environmental Protection Agency · USHelmholtz Zentrum München · DEOak Ridge Associated Universities · US

Funding

u.s. environmental protection agency U.S. Environmental Protection Agency Intramural Research Program
6 · The paper itself

Abstract

backgroundShort-term exposure to ambient nitrogen dioxide (NO

methodsSixty-two healthy participants were enrolled into low or high omega-3 groups based on their habitual omega-3 PUFA intake. Each participant was repeatedly assessed for lung function, blood lipids, markers of coagulation and fibrinolysis, vascular function, and heart rate variability (HRV) in up to five sessions, each separated by at least 7 days. This study was carried out in the Research Triangle area of North Carolina, USA between October 2016 and September 2019. Daily ambient NO

resultsThe average concentration of ambient NO

conclusionsThe results in this study imply that dietary omega-3 PUFA consumption may offer respiratory and vascular benefits in response to short-term exposure of healthy adults to NO

trial registrationClinicalTrials.gov ( NCT02921048 ).

Indexed as

Air PollutantsAir PollutionAdultEatingEnvironmental ExposureFatty Acids, UnsaturatedHumansLungNitrogen DioxideParticulate MatterAir PollutantsFatty Acids, UnsaturatedNitrogen DioxideParticulate MatterAir pollutionCardiovascularLung functionNitrogen dioxideOmega-3 polyunsaturated fatty acids

Identifiers

PMID34872587
PMCPMC8650256
OpenAlexW4200594279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.