Evidence map›Paper›PMID 34872358›Full record

ArticlemBio2021

A Hyperthermoactive-Cas9 Editing Tool Reveals the Role of a Unique Arsenite Methyltransferase in the Arsenic Resistance System of Thermus thermophilus HB27.

Giovanni Gallo, Ioannis Mougiakos, Mauricio Bianco, Miriam Carbonaro, Andrea Carpentieri, Anna Illiano, Pietro Pucci, Simonetta Bartolucci, John van der Oost, Gabriella Fiorentino

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Expression and Functional Analysis of the Compact ThermophilicInternational journal of molecular sciences · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Giovanni Gallo *Department of Biology, University of Naples Federico IIgrid.4691.a, Naples, Italy.ORCID 0000-0001-6846-6526
Ioannis Mougiakos *Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.ORCID 0000-0001-8853-8208
Mauricio BiancoLaboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.
Miriam CarbonaroDepartment of Biology, University of Naples Federico IIgrid.4691.a, Naples, Italy.ORCID 0000-0001-9336-3262
Andrea CarpentieriDepartment of Chemical Sciences, University of Naples Federico IIgrid.4691.a, Naples, Italy.ORCID 0000-0002-1944-5355
Anna IllianoCEINGE-Biotecnologie avanzate, Naples, Italy.
Pietro PucciCEINGE-Biotecnologie avanzate, Naples, Italy.ORCID 0000-0002-5885-1495
Simonetta BartolucciDepartment of Biology, University of Naples Federico IIgrid.4691.a, Naples, Italy.ORCID 0000-0002-1968-2959
John van der OostLaboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.ORCID 0000-0001-5024-1871
Gabriella FiorentinoDepartment of Biology, University of Naples Federico IIgrid.4691.a, Naples, Italy.ORCID 0000-0002-4089-3822
University of Naples Federico II · ITCeinge Biotecnologie Avanzate (Italy) · ITNational Research Council · ITWageningen University & Research · NLHelmholtz Centre for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arsenic detoxification systems can be found in a wide range of organisms, from bacteria to humans. In a previous study, we discovered an arsenic-responsive transcriptional regulator in the thermophilic bacterium Thermus thermophilus HB27 (

Indexed as

Amino Acid SequenceArsenicBacterial ProteinsBinding SitesCRISPR-Cas SystemsEnzyme StabilityGene EditingMethyltransferasesSequence AlignmentThermus thermophilusArsenicarsenite methyltransferaseBacterial ProteinsMethyltransferasesarsenic resistancebioreporterCRISPR-Cas9 genome editingextremophilesgenetic toolthermoresistanceThermus thermophilus

Identifiers

PMID34872358
PMCPMC8649762
OpenAlexW4225857423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.