Evidence map›Paper›PMID 34871985›Full record

ReviewPoultry science2022

Phytochemical control of poultry coccidiosis: a review.

Nahed A El-Shall, Mohamed E Abd El-Hack, Najah M Albaqami, Asmaa F Khafaga, Ayman E Taha, Ayman A Swelum, Mohamed T El-Saadony, Heba M Salem, Amira M El-Tahan, Synan F AbuQamar and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Poultry science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
24.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 218 citations in OpenAlex.

  1. Article
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  15. Avian PathogenicVeterinary sciences · 2025
    Review
  16. Exploring the interplay betweenThe veterinary quarterly · 2025
    Review
  17. Simultaneous Detection and Differentiation of FourAnimals : an open access journal from MDPI · 2025
    Article
  18. Article
  19. Review
  20. Synergistic Enhancement ofAnimals : an open access journal from MDPI · 2025
    Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 4 countries.

Nahed A El-ShallDepartment of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Alexandria University, Edfina, Elbehira 22758, Egypt.
Mohamed E Abd El-HackPoultry Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.
Najah M AlbaqamiDepartment of Biological Sciences, Zoology, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Asmaa F KhafagaDepartment of Pathology, Faculty of Veterinary Medicine, Alexandria University, Edfina 22758, Egypt.
Ayman E TahaDepartment of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Edfina 22758, Egypt.
Ayman A SwelumDepartment of Theriogenology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
Mohamed T El-SaadonyDepartment of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig 44511 , Egypt.
Heba M SalemDepartment of Poultry Diseases, Faculty of Veterinary Medicine, Cairo University, Giza 12211 , Egypt.
Amira M El-TahanPlant Production Department, Arid Lands Cultivation Research Institute, The City of Scientific Research and Technological Applications, Alexandria, Egypt.
Synan F AbuQamarDepartment of Biology, College of Science, United Arab Emirates University, Al-Ain,15551, United Arab Emirates.
Khaled A El-TarabilyDepartment of Biology, College of Science, United Arab Emirates University, Al-Ain,15551, United Arab Emirates; Harry Butler Institute, Murdoch University, Murdoch, 6150, Western Australia, Australia. Electronic address: ktarabily@uaeu.ac.ae.
Ahmed R ElbestawyPoultry and Fish Diseases Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.
Alexandria University · EGZagazig University · EGCairo University · EGCity of Scientific Research and Technological Applications · EGDamanhour University · EGKing Abdulaziz University · SAMurdoch University · AUUnited Arab Emirates University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Avian coccidiosis is a major parasitic disorder in chickens resulting from the intracellular apicomplexan protozoa Eimeria that target the intestinal tract leading to a devastating disease. Eimeria life cycle is complex and consists of intra- and extracellular stages inducing a potent inflammatory response that results in tissue damage associated with oxidative stress and lipid peroxidation, diarrheal hemorrhage, poor growth, increased susceptibility to other disease agents, and in severe cases, mortality. Various anticoccidial drugs and vaccines have been used to prevent and control this disorder; however, many drawbacks have been reported. Drug residues concerning the consumers have directed research toward natural, safe, and effective alternative compounds. Phytochemical/herbal medicine is one of these natural alternatives to anticoccidial drugs, which is considered an attractive way to combat coccidiosis in compliance with the "anticoccidial chemical-free" regulations. The anticoccidial properties of several natural herbal products (or their extracts) have been reported. The effect of herbal additives on avian coccidiosis is based on diminishing the oocyst output through inhibition or impairment of the invasion, replication, and development of Eimeria species in the gut tissues of chickens; lowering oocyst counts due to the presence of phenolic compounds in herbal extracts which reacts with cytoplasmic membranes causing coccidial cell death; ameliorating the degree of intestinal lipid peroxidation; facilitating the repair of epithelial injuries; and decreasing the intestinal permeability induced by Eimeria species through the upregulation of epithelial turnover. This current review highlights the anticoccidial activity of several herbal products, and their other beneficial effects.

Indexed as

CoccidiosisEimeriaAnimalsChickensPhytochemicalsPoultryPhytochemicalschickencoccidiosiscontrolEimeriaherbs

Identifiers

PMID34871985
PMCPMC8649401
OpenAlexW3207684448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.