Evidence map›Paper›PMID 34871931›Full record

ArticleMedical image analysis2022

Embracing the disharmony in medical imaging: A Simple and effective framework for domain adaptation.

Rongguang Wang, Pratik Chaudhari, Christos Davatzikos

Abstract read
In one paragraph

Article in Medical image analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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  7. The impact of scanner domain shift on deep learning performance in medical imaging: an experimental study.International journal of computer assisted radiology and surgery · 2026
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  12. Source-Free Active Learning for Adapting Alzheimer's Diagnostic Deep Learning Models Across Neuroimaging Cohorts.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2025
    Article
  13. Review
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  16. A Physics-Informed Deep Neural Network for Harmonization of CT Images.IEEE transactions on bio-medical engineering · 2024
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rongguang WangDepartment of Electrical and Systems Engineering, University of Pennsylvania, PA, USA; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, USA. Electronic address: rgw@seas.upenn.edu.
Pratik ChaudhariDepartment of Electrical and Systems Engineering, University of Pennsylvania, PA, USA; General Robotics, Automation, Sensing and Perception (GRASP) Laboratory, University of Pennsylvania, USA. Electronic address: pratikac@seas.upenn.edu.
Christos DavatzikosDepartment of Electrical and Systems Engineering, University of Pennsylvania, PA, USA; Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, USA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, USA. Electronic address: christos.davatzikos@pennmedicine.upenn.edu.

Funding

Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Machine Learning and Large-scale Imaging analytics for dimensional representations of brain trajectories in aging and preclinical Alzheimer's Disease: The brain aging chart and the iSTAGING consortiumRF1AG054409 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2023
$6.3M
Mapping Heterogeneity of Neuroanatomical Imaging Signatures of Psychosis via Pattern AnalysisR01MH112070 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2020
$2.7M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
NIA NIH HHS RF1 AG054409NIA NIH HHS U01 AG068057NIH HHS S10 OD023495NIMH NIH HHS R01 MH112070
6 · The paper itself

Abstract

Domain shift, the mismatch between training and testing data characteristics, causes significant degradation in the predictive performance in multi-source imaging scenarios. In medical imaging, the heterogeneity of population, scanners and acquisition protocols at different sites presents a significant domain shift challenge and has limited the widespread clinical adoption of machine learning models. Harmonization methods, which aim to learn a representation of data invariant to these differences are the prevalent tools to address domain shift, but they typically result in degradation of predictive accuracy. This paper takes a different perspective of the problem: we embrace this disharmony in data and design a simple but effective framework for tackling domain shift. The key idea, based on our theoretical arguments, is to build a pretrained classifier on the source data and adapt this model to new data. The classifier can be fine-tuned for intra-study domain adaptation. We can also tackle situations where we do not have access to ground-truth labels on target data; we show how one can use auxiliary tasks for adaptation; these tasks employ covariates such as age, gender and race which are easy to obtain but nevertheless correlated to the main task. We demonstrate substantial improvements in both intra-study domain adaptation and inter-study domain generalization on large-scale real-world 3D brain MRI datasets for classifying Alzheimer's disease and schizophrenia.

Indexed as

Alzheimer DiseaseMachine LearningHumansMagnetic Resonance ImagingNeuroimagingRadiographyDistribution shiftDomain adaptationDomain generalizationHeterogeneityMRI

Identifiers

PMID34871931
PMCPMC8792340

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.