Evidence map›Paper›PMID 34871896›Full record

ArticleJournal of biomechanics2022

Structure-function relationships of TMJ lateral capsule-ligament complex.

Cherice N Hill, Matthew C Coombs, Sarah E Cisewski, Emily L Durham, Daniel J Bonthius, Gregg M Gardner, Ethan C Lopez, Marshall B Wilson, James J Cray, Hai Yao

Open access · greenAbstract read
In one paragraph

Article in Journal of biomechanics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Cherice N HillDepartment of Bioengineering, Clemson University, Clemson, SC, United States; Department of Oral Health Sciences, Medical University of South Carolina, Charleston, SC, United States.
Matthew C CoombsDepartment of Bioengineering, Clemson University, Clemson, SC, United States; Department of Oral Health Sciences, Medical University of South Carolina, Charleston, SC, United States.
Sarah E CisewskiDepartment of Oral Health Sciences, Medical University of South Carolina, Charleston, SC, United States.
Emily L DurhamDepartment of Oral Health Sciences, Medical University of South Carolina, Charleston, SC, United States.
Daniel J BonthiusDepartment of Bioengineering, Clemson University, Clemson, SC, United States.
Gregg M GardnerDepartment of Bioengineering, Clemson University, Clemson, SC, United States.
Ethan C LopezDepartment of Bioengineering, Clemson University, Clemson, SC, United States.
Marshall B WilsonDepartment of Bioengineering, Clemson University, Clemson, SC, United States.
James J CrayDepartment of Biomedical Education and Anatomy, College of Medicine, The Ohio State University, Columbus, OH, United States; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, United States.
Hai YaoDepartment of Bioengineering, Clemson University, Clemson, SC, United States; Department of Oral Health Sciences, Medical University of South Carolina, Charleston, SC, United States. Electronic address: haiyao@clemson.edu.
Medical University of South Carolina · USClemson University · USThe Ohio State University · US

Funding

Tissue Structural and Neural Remodeling in Human Sacroiliac JointP20GM121342 · NIGMS · CLEMSON UNIVERSITY · PI Shangping Wang · 2018 to 2026
$24.7M
T-COHR: Training in Craniofacial and Oral Health ResearchT32DE017551 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAO, HAI · 2006 to 2025
$10.3M
Integrating craniofacial morphology, oral function, temporomandibular biomechanics and mechanobiology to determine sex-specific TMJ pathophysiology in humansR01DE021134 · NIDCR · CLEMSON UNIVERSITY · PI YAO, HAI · 2012 to 2025
$4.7M
Biophysical Modeling of Fluid and Solute Transport in the TMJ DiscR03DE018741 · NIDCR · CLEMSON UNIVERSITY · PI YAO, HAI · 2009 to 2010
$223k
The effects of pharmacological exposures on cranial suture stem cellsF31DE026684 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DURHAM, EMILY LENSIE · 2017 to 2018
$90k
Structure-function relationships between human temporomandibular lateral capsule-ligament complex tensile stiffness, collagen ultrastructure and ECM composition: Investigation of sexual dimorphismsF32DE027864 · NIDCR · CLEMSON UNIVERSITY · PI COOMBS, MATTHEW CHATTERJEE · 2018 to 2018
$40k
NIDCR NIH HHS F31 DE026684NIDCR NIH HHS F32 DE027864NIDCR NIH HHS R01 DE021134NIDCR NIH HHS R03 DE018741NIDCR NIH HHS T32 DE017551NIGMS NIH HHS P20 GM121342
6 · The paper itself

Abstract

The human temporomandibular joint (TMJ) lateral capsule ligament (LCL) complex is debated as a fibrous capsule with distinct ligaments or ligamentous thickening, necessitating further evaluation of the complex and its role in TMJ anatomy and mechanics. This study explores the ultrastructural arrangement, biomechanical tensile properties, and biochemical composition of the human LCL complex including region-specific differences to explore the presence of a distinct temporomandibular ligament and sex-specific differences to inform evaluations of potential etiological mechanisms. LCL complex ultrastructural arrangement, biomechanical properties, and biochemical composition were determined using cadaveric samples. Statistical modeling assessed sex- and region-specific effects on LCL complex tissue properties. Collagen fiber coherency, collagen fiber bundle size, and elastin fiber count did not differ between sexes, but females trended higher in elastin fiber count. LCL complex water and sGAG content did not differ between sexes or regions, but collagen content was higher in the anterior region (311.0 ± 185.6 μg/mg) compared to the posterior region (221.0 ± 124.9 μg/mg) (p = 0.045) across sexes and in males (339.6 ± 170.6 μg/mg) compared to females (204.5 ± 130.7 μg/mg) (p = 0.006) across regions. Anterior failure stress (1.1 ± 0.7 MPa) was larger than posterior failure stress (0.6 ± 0.4 MPa) (p = 0.024). Regional differences confirm the presence of a mechanically and compositionally distinct temporomandibular ligament. Baseline sex-specific differences are critical for etiological investigations of sex disparities in TMJ disorders. These results have important biomechanical and clinical ramifications, providing critical baseline tissue material properties, informing the development of TMJ musculoskeletal models, and identifying new areas for etiologic investigations for temporomandibular disorders.

Indexed as

Temporomandibular JointTemporomandibular Joint DisordersBiomechanical PhenomenaCollagenFemaleHumansLigaments, ArticularMaleStructure-Activity RelationshipCollagenExtracellular matrix compositionSecond harmonic generation microscopyTemporomandibular joint disordersTissue biomechanicsTissue ultrastructure

Identifiers

PMID34871896
PMCPMC8724391
OpenAlexW3216059629

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.