ArticleJournal of neuroimmunology2022
Relationships between cytokines and cognitive function from pre- to post-chemotherapy in patients with breast cancer.
Article in Journal of neuroimmunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Trial
- Evaluating the suitability of the Perceive, Recall, Plan and Perform System of Task Analysis (PRPP-A) for assessing work-related cognitive difficulties in women after breast cancer: A comparison with Cambridge Neuropsychological Test Automated Battery (CANTAB).Australian occupational therapy journal · 2026Review
- Cancer treatment-related cognitive impairment.Neuro-oncology advances · 2026Review
- Review
- The Inflammatory Footprint of Anti-Breast Cancer Treatments and Psychosocial Factors in Women Undergoing Chemotherapy.Biomedicines · 2025Article
- Inflammation and dimensions of fatigue in women with early stage breast cancer: A longitudinal examination.Cancer · 2025Article
- Article
- Biomarker-based profiling of fatigue in childhood cancer survivors: evidence for distinct inflammatory and glial-associated profiles.Brain, behavior, & immunity - health · 2025Article
- Blood Clock Correlation Distance (BloodCCD) as a novel marker to detect circadian rhythm disruption in cancer survivors with insomnia.BJC reports · 2025Article
- The course of self-perceived cognitive functioning among patients with lymphoma and the co-occurrence with fatigue and psychological distress.Journal of cancer survivorship : research and practice · 2025Article
- Cancer-Related Cognitive Impairment and the Potential of Dietary Interventions for the Prevention and Mitigation of Neurodegeneration.Cancer research · 2025Review
- Effect and clinical mechanism exploration of acupuncture intervention for chemotherapy-related cognitive impairment (CRCI) in triple-negative breast cancer: study protocol for a randomized controlled trial.Frontiers in neurology · 2025Article
- Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer.Journal of experimental & clinical cancer research : CR · 2024Review
- Development and validation of a risk prediction model for cognitive impairment in breast cancer patients.BMC psychiatry · 2024Article
- Changes in S100 calcium-binding protein β (S100β) and cognitive function from pre- to post-chemotherapy among women with breast cancer.Brain, behavior, & immunity - health · 2024Article
- Inflammation at diagnosis and cognitive impairment two years later in breast cancer patients from the Canto-Cog study.Breast cancer research : BCR · 2024Article
- Effects of mammary cancer and chemotherapy on neuroimmunological markers and memory function in a preclinical mouse model.Brain, behavior, & immunity - health · 2023Article
- Article
- The high burden of symptoms associated with cognitive impairment in lung cancer patients: A latent class analysis.Asia-Pacific journal of oncology nursing · 2023Article
- Elevated C-Reactive Protein and Subsequent Patient-Reported Cognitive Problems in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
Cancer-related cognitive decline (CRCD) is a clinically important problem and negatively affects daily functioning and quality of life. We conducted a pilot longitudinal study from pre- to post-chemotherapy in patients with breast cancer to assess changes in inflammation and cognition over time, as well as the impact of baseline cytokine level on post-chemotherapy cognitive scores. We found that concentrations of IL-6, MCP-1, sTNFRI, and sTNFRII significantly increased in patients, while IL-1β significantly decreased (p < 0.05). After controlling for covariates, increases in IL-6 and MCP-1 were associated with worse executive function and verbal fluency in patients from pre- to post-chemotherapy (p < 0.05). Higher baseline IL-6 was associated with better performance on executive function and verbal fluency post chemotherapy (p < 0.05). Overall, these results suggest that chemotherapy-associated increases in cytokines/receptors is associated with worse cognitive function. Larger studies are needed to confirm these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.