ReviewAgeing research reviews2022
Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics.
Review in Ageing research reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Atherosclerosis after pre-eclampsia: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Pooled it
- Cross-ancestry genome-wide association study identifies new susceptibility genes for preeclampsia.BMC pregnancy and childbirth · 2025Pooled it
- Investigating genetic links between biological aging and adverse pregnancy outcomes.Biogerontology · 2025Pooled it
- Raised levels of chemerin in women with preeclampsia: A meta-analysis.Biomolecules & biomedicine · 2024Pooled it
- Single-cell and spatial transcriptomics identify SPP1 + trophoblast necroptosis as a potential contributor to late-onset preeclampsia via SPP1-CD44-mediated interaction with macrophages.Journal of translational medicine · 2026Article
- Reduced HSD17B1 expression in preeclampsia: integrated transcriptomic, summary Mendelian randomization, immune deconvolution, and experimental validation.BMC pregnancy and childbirth · 2026Article
- FABP4 is highly expressed in preeclamptic placentas and regulates trophoblast lipid metabolism, mitochondrial function, and oxidative stress in vitro.BMC pregnancy and childbirth · 2026Article
- PPP1R1C: a specific placental mRNA biomarker for distinguishing preeclampsia from healthy pregnancies.BMC pregnancy and childbirth · 2026Article
- L-(+)-Ergothioneine ameliorates preeclampsia-associated vascular endothelial dysfunction by modulating the Nrf2-PPARγ-sFlt-1 axis.PloS one · 2026Article
- Red Cell Distribution Width-to-Albumin Ratio as a Predictor of Preeclampsia in Advanced Maternal Age: A Retrospective Cohort Study.International journal of women's health · 2026Article
- A retrospective analysis of BMI/TP ratio and its predictive role in gestational hypertension outcomes.Medicine · 2025Observational
- Alterations in serum mir-4745-5p levels and their diagnostic value in preeclampsia patients.Journal of human hypertension · 2025Article
- Genetic factors in the risk assessment of preeclampsia: a review of recent findings.Molecular biology reports · 2025Review
- APPL1 concentration as a potential biomarker in early-onset preeclampsia: correlations with adiponectin-leptin dysregulation and adverse neonatal outcomes.BMC pregnancy and childbirth · 2025Article
- [Correlation betweenZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- The optimal childbearing age and birth spacing in china: a multicenter retrospective cohort study.BMC public health · 2025Article
- Integrated multi-omics analysis reveals immunovascular mechanisms of the placenta-maternal brain axis and lifespan neurobehavior changes in a mouse model of preeclampsia.Neuroscience · 2025Article
- Active chromatin marks and up-regulation of FOXC1 in uterine epithelial cells demarcate the onset of reproductive decline in aging females.NAR molecular medicine · 2025Article
- Artificial intelligence-derived retinal age gap as a marker for reproductive aging in women.NPJ digital medicine · 2025Article
- ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression.eLife · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Women live longer than men but experience greater disability and a longer period of illness as they age. Despite clear sex differences in aging, the impact of pregnancy and its complications, such as preeclampsia, on aging is an underexplored area of geroscience. This review summarizes our current knowledge about the complex links between pregnancy and age-related diseases, including evidence from epidemiology, clinical research, and genetics. We discuss the relationship between normal and pathological pregnancy and maternal aging, using preeclampsia as a primary example. We review the results of human genetics studies of preeclampsia, including genome wide association studies (GWAS), and attempted to catalog genes involved in preeclampsia as a gateway to mechanisms underlying an increased risk of later life cardio- and neuro- vascular events. Lastly, we discuss challenges in interpreting the GWAS of preeclampsia and provide a functional genomics framework for future research needed to fully realize the promise of GWAS in identifying targets for geroprotective prevention and therapeutics against preeclampsia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.