Evidence map›Paper›PMID 34871179›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM.

Wei Zheng, Fan Li, Zhanyu Ding, Hao Liu, Lei Zhu, Cong Xu, Jiawei Li, Qi Gao, Yanxing Wang, Zhenglin Fu and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Compound heterozygousAME case reports · 2026
    Article
  5. BiallelicFrontiers in genetics · 2026
    Article
  6. Review
  7. Heterogeneity of radial spoke components in Tetrahymena cilia.Cellular and molecular life sciences : CMLS · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Structural determination and modeling of ciliary microtubules.Acta crystallographica. Section D, Structural biology · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Formation and function of multiciliated cells.The Journal of cell biology · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Wei ZhengState Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0003-4276-2006
Fan LiUniversity of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0002-9895-3517
Zhanyu DingState Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
Hao LiuUniversity of Chinese Academy of Sciences, Beijing 100049, China.
Lei ZhuUniversity of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0002-9110-2445
Cong XuState Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0001-8787-3987
Jiawei LiState Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
Qi GaoUniversity of Chinese Academy of Sciences, Beijing 100049, China.
Yanxing WangState Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-9523-0030
Zhenglin FuState Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-2574-3412
Chao PengNational Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Shanghai 201210, China.
Xiumin YanState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; yanx@sibcb.ac.cn xlzhu@sibcb.ac.cn cong@sibcb.ac.cn.ORCID 0000-0002-3260-1690
Xueliang ZhuUniversity of Chinese Academy of Sciences, Beijing 100049, China; yanx@sibcb.ac.cn xlzhu@sibcb.ac.cn cong@sibcb.ac.cn.ORCID 0000-0001-8019-9336
Yao CongState Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; yanx@sibcb.ac.cn xlzhu@sibcb.ac.cn cong@sibcb.ac.cn.
Chinese Academy of Sciences · CNShanghai Advanced Research Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The radial spoke (RS) heads of motile cilia and flagella contact projections of the central pair (CP) apparatus to coordinate motility, but the morphology is distinct for protozoa and metazoa. Here we show the murine RS head is compositionally distinct from that of

Indexed as

AnimalsAntigens, SurfaceAxonemeChlamydomonasCiliaCryoelectron MicroscopyCytoskeletal ProteinsDNA-Binding ProteinsEpitopesFlagellaHEK293 CellsHumansMiceModels, MolecularMutationProtein ConformationAntigens, SurfaceCytoskeletal ProteinsDNA-Binding ProteinsEpitopesNZ-1 testis-specific antigen, mouseRecombinant ProteinsRSPH1 protein, humanRSPH4A protein, humanRSPH9 protein, humanciliacryo-EMflagellaprimary ciliary dyskinesiaradial spoke

Identifiers

PMID34871179
PMCPMC7848523
OpenAlexW3121847432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.