Evidence map›Paper›PMID 34871166›Full record

ArticleeLife2021

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of

Nicholas Rinkenberger, Michael E Abrams, Sumit K Matta, John W Schoggins, Neal M Alto, L David Sibley

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Integrative omics and multi-cohort identifyJournal of biomedical research · 2025
    Article
  6. Recent Progress inInternational journal of molecular sciences · 2025
    Review
  7. Interferon-Science (New York, N.Y.) · 2024
    Review
  8. Review
  9. Article
  10. A Combination of Four Nuclear Targeted Effectors ProtectsbioRxiv : the preprint server for biology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. PLAAT1 inhibits type I interferon responseFrontiers in immunology · 2022
    Article
  20. Forward Genetics in Apicomplexa Biology: The Host Side of the Story.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicholas RinkenbergerDepartment of Molecular Microbiology, Washington University in St. Louis, St Louis, United States.
Michael E AbramsDepartment of Microbiology, University of Texas Southwestern, Dallas, United States.
Sumit K MattaDepartment of Molecular Microbiology, Washington University in St. Louis, St Louis, United States.
John W SchogginsDepartment of Microbiology, University of Texas Southwestern, Dallas, United States.ORCID https://orcid.org/0000-0002-7944-6800
Neal M AltoDepartment of Microbiology, University of Texas Southwestern, Dallas, United States.ORCID https://orcid.org/0000-0002-7602-3853
L David SibleyDepartment of Molecular Microbiology, Washington University in St. Louis, St Louis, United States.ORCID https://orcid.org/0000-0001-7110-0285
The University of Texas Southwestern Medical Center · USWashington University in St. Louis · US

Funding

Type III effector regulation of host signal transduction systemsR01AI083359 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI ALTO, NEAL MATHEW · 2009 to 2024
$6.3M
Molecular Basis of Human ToxoplasmosisR01AI118426 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2015 to 2024
$6.0M
A functional evolutionary genetic approach to combat viral infectionDP1AI158124 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SCHOGGINS, JOHN W. · 2020 to 2024
$5.7M
Type III effector regulation of host GTPase signalingR56AI083359 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI ALTO, NEAL MATHEW · 2014 to 2014
$452k
Interferon-mediated control mechanisms in human cellsR21AI154048 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2020 to 2021
$433k
NIAID NIH HHS DP1 AI158124NIAID NIH HHS R01 AI083359NIAID NIH HHS R01 AI118426NIAID NIH HHS R21 AI154048NIAID NIH HHS R56 AI083359
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene ExpressionHost-Parasite InteractionsA549 CellsGene LibraryHEK293 CellsHeLa CellsHumansImmunity, InnateInterferon-gammaReceptors, Retinoic AcidToxoplasmaInterferon-gammaPLAAT4 protein, humanReceptors, Retinoic Acidcell deathegressgrowth restrictioninfectious diseaseinterferon gammaintracellular parasitemicrobiologyToxoplasma

Identifiers

PMID34871166
PMCPMC8789288
OpenAlexW4226051617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.