Evidence map›Paper›PMID 34871093›Full record

ArticleAntimicrobial agents and chemotherapy2022

New Delhi Metallo-Beta-Lactamase Facilitates the Emergence of Cefiderocol Resistance in Enterobacter cloacae.

Dennis Nurjadi, Kaan Kocer, Quan Chanthalangsy, Sabrina Klein, Klaus Heeg, Sébastien Boutin

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 87 citations in OpenAlex.

  1. ISEmerging microbes & infections · 2026
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  8. High-risk clonal expansion of IMP-producingAntimicrobial agents and chemotherapy · 2025
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  13. Combined resistance mechanisms leading to high-level of cefiderocol resistance among NDM-like producing E. coli ST167 clinical isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dennis NurjadiDepartment of Infectious Diseases, Medical Microbiology and Hospital Hygiene, University Hospital Heidelberggrid.5253.1, Heidelberg, Germany.ORCID 0000-0002-1278-5939
Kaan KocerDepartment of Infectious Diseases, Medical Microbiology and Hospital Hygiene, University Hospital Heidelberggrid.5253.1, Heidelberg, Germany.ORCID 0000-0002-1134-4197
Quan ChanthalangsyDepartment of Infectious Diseases, Medical Microbiology and Hospital Hygiene, University Hospital Heidelberggrid.5253.1, Heidelberg, Germany.
Sabrina KleinDepartment of Infectious Diseases, Medical Microbiology and Hospital Hygiene, University Hospital Heidelberggrid.5253.1, Heidelberg, Germany.
Klaus HeegDepartment of Infectious Diseases, Medical Microbiology and Hospital Hygiene, University Hospital Heidelberggrid.5253.1, Heidelberg, Germany.
Sébastien BoutinDepartment of Infectious Diseases, Medical Microbiology and Hospital Hygiene, University Hospital Heidelberggrid.5253.1, Heidelberg, Germany.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cefiderocol is a promising novel siderophore cephalosporin for the treatment of multidrug-resistant Gram-negative bacilli and with stability against degradation by metallo-β-lactamases. Nonetheless, the emergence of cefiderocol in metallo-β-lactamase-producing Enterobacterales during therapy has been reported on more than one occasion. To understand the underlying mechanisms and factors facilitating the resistance development, we conducted an

Indexed as

Anti-Bacterial AgentsEnterobacter cloacaebeta-LactamasesCefiderocolCephalosporinsDrug Resistance, Multiple, BacterialMicrobial Sensitivity TestsAnti-Bacterial Agentsbeta-lactamase NDM-1beta-LactamasesCefiderocolCephalosporinsantibiotic resistancecarbapenem resistancecefiderocolcefiderocol resistancedrug resistance mechanismsEnterobacteralesEnterobacter cloacaeNew Delhi metallo-β-lactamase

Identifiers

PMID34871093
PMCPMC8846454
OpenAlexW4200252685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.