Evidence map›Paper›PMID 34871042›Full record

ArticleInfection and immunity2022

Loss of an Intimin-Like Protein Encoded on a Uropathogenic E. coli Pathogenicity Island Reduces Inflammation and Affects Interactions with the Urothelium.

Allyson E Shea, Jolie A Stocki, Stephanie D Himpsl, Sara N Smith, Harry L T Mobley

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. The Role ofInternational journal of molecular sciences · 2025
    Review
  3. Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Allyson E SheaDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.ORCID 0000-0003-1329-3888
Jolie A StockiDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Stephanie D HimpslDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Sara N SmithDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Harry L T MobleyDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.ORCID 0000-0001-9195-7665
University of Michigan · US

Funding

Reciprocal Control of Motility and Adherence in UTIR01AI059722 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PEARSON, MELANIE M. · 2005 to 2024
$7.4M
Characterization of pathogen nutrient acquisition and transport systems required during UTIF32AI147527 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHEA, ALLYSON E · 2019 to 2022
$198k
NIAID NIH HHS F32 AI147527NIAID NIH HHS R01 AI059722
6 · The paper itself

Abstract

Uropathogenic Escherichia coli (UPEC) causes the majority of uncomplicated urinary tract infections (UTI), which affect nearly half of women worldwide. Many UPEC strains carry an annotated intimin-like adhesin (

Indexed as

Escherichia coli InfectionsEscherichia coli ProteinsUrinary Tract InfectionsUropathogenic Escherichia coliAdhesins, BacterialAnimalsFemaleGenomic IslandsHumansInflammationMaleMiceUrotheliumAdhesins, BacterialEscherichia coli ProteinsadhesinsEscherichia coliintimininvasinurinary tract infectionvirulence

Identifiers

PMID34871042
PMCPMC8853676
OpenAlexW4200309360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.