Evidence map›Paper›PMID 34871030›Full record

ArticleJournal of bacteriology2022

The WalR-WalK Signaling Pathway Modulates the Activities of both CwlO and LytE through Control of the Peptidoglycan Deacetylase PdaC in Bacillus subtilis.

Genevieve S Dobihal, Josué Flores-Kim, Ian J Roney, Xindan Wang, David Z Rudner

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. A broadly conserved gram-positive lipoprotein regulates cell elongation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
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  7. ThebioRxiv : the preprint server for biology · 2025
    Article
  8. Article
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  11. mBio · 2025
    Article
  12. Article
  13. Article
  14. PgpP is a broadly conserved phosphatase required for phosphatidylglycerol lipid synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Genevieve S DobihalDepartment of Microbiology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Josué Flores-KimDepartment of Microbiology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Ian J RoneyDepartment of Microbiology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Xindan WangDepartment of Biology, Indiana University Bloomington, Bloomington, Indiana, USA.ORCID 0000-0001-6458-180X
David Z RudnerDepartment of Microbiology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.ORCID 0000-0002-0236-7143
Harvard University · USIndiana University Bloomington · US

Funding

Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI KASPER, DENNIS L. · 2014 to 2018
$25.2M
Chromosome Dynamics in Bacillus SubtillsR01GM086466 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2009 to 2021
$4.2M
Growth and differentiation in Bacillus subtilisR35GM145299 · NIGMS · HARVARD MEDICAL SCHOOL · PI DAVID Z RUDNER · 2022 to 2026
$2.9M
How bacterial SMC complexes organize chromosomes (Equipment Supplement)R01GM141242 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI WANG, XINDAN · 2021 to 2025
$1.8M
Bacteriology PhD Training ProgramT32AI132120 · NIAID · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2017 to 2021
$1.7M
Cell Envelope Homeostasis in Bacillus subtilisR01GM127399 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2019 to 2022
$1.4M
NIAID NIH HHS 5T32AI132120NIAID NIH HHS F32AI36431NIAID NIH HHS T32 AI132120NIAID NIH HHS U19 AI109764NIGMS NIH HHS GM086466NIGMS NIH HHS GM127399NIGMS NIH HHS GM141242NIGMS NIH HHS R01 GM086466NIGMS NIH HHS R01 GM127399NIGMS NIH HHS R01 GM141242NIGMS NIH HHS R35 GM145299
6 · The paper itself

Abstract

The WalR-WalK two component signaling system in Bacillus subtilis functions in the homeostatic control of the peptidoglycan (PG) hydrolases LytE and CwlO that are required for cell growth. When the activities of these enzymes are low, WalR activates transcription of

Indexed as

Bacillus subtilisBacterial ProteinsCell WallGene Expression Regulation, BacterialN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanSignal TransductionBacterial ProteinsLytE protein, Bacillus subtilisN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanYycF protein, Bacteriadeacetylationd,l-endopeptidasepeptidoglycantwo component system

Identifiers

PMID34871030
PMCPMC8846395
OpenAlexW4200247971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.