Evidence map›Paper›PMID 34871024›Full record

ArticleJournal of psychopathology and clinical science2022

Estimating the symptom structure of bipolar disorder via network analysis: Energy dysregulation as a central symptom.

Richard J McNally, Donald J Robinaugh, Thilo Deckersbach, Louisa G Sylvia, Andrew A Nierenberg

Abstract read
In one paragraph

Article in Journal of psychopathology and clinical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Richard J McNallyDepartment of Psychology, Harvard University.ORCID 0000-0002-5228-8777
Donald J RobinaughMassachusetts General Hospital.
Thilo DeckersbachMassachusetts General Hospital.
Louisa G SylviaMassachusetts General Hospital.
Andrew A NierenbergMassachusetts General Hospital.

Funding

Network Psychiatry: Using Network Science to Advance Our Understanding of Post-Bereavement PsychopathologyK23MH113805 · NIMH · NORTHEASTERN UNIVERSITY · PI ROBINAUGH, DONALD JOHN · 2018 to 2022
$988k
NIMH NIH HHS K23 MH113805
6 · The paper itself

Abstract

Using network analysis, we estimated the structure of relations among manic and depressive symptoms, respectively, in 486 patients (59% women; age: M = 37, SD = 12.1) with bipolar disorder prior to their entering a clinical trial. We computed three types of networks: (a) Gaussian graphical models (GGMs) depicting regularized partial correlations, (b) regression-based GGMs depicting nonregularized partial correlations, and (c) directed acyclic graphs (DAGs) via a Bayesian hill-climbing algorithm. Low energy and elevated energy were consistently identified as central nodes in the GGMs and as key parent nodes in the DAGs. Across analyses, pessimism about the future and depressed mood were the symptoms most strongly associated with suicidal thoughts and behavior. These exploratory analyses provide rich information about how bipolar disorder symptoms relate to one another, thereby furnishing a foundation for investigating how bipolar disorder symptoms may operate as a causal system. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Indexed as

Bipolar DisorderBayes TheoremFemaleHumansMaleManiaNormal DistributionSuicidal Ideation

Identifiers

PMID34871024
PMCPMC9168523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.