Evidence map›Paper›PMID 34870928›Full record

ArticleAIDS (London, England)2021

TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection.

Michael T Boswell, Louis-Marie Yindom, Dan Hameiri-Bowen, Grace McHugh, Ethel Dauya, Tsitsi Bandason, Hilda Mujuru, Joakim Esbjörnsson, Rashida A Ferrand, Sarah Rowland-Jones

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PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Michael T BoswellNuffield Department of Medicine, Oxford University, UK.
Louis-Marie YindomNuffield Department of Medicine, Oxford University, UK.
Dan Hameiri-BowenNuffield Department of Medicine, Oxford University, UK.
Grace McHughBiomedical Research and Training Institute, Zimbabwe.
Ethel DauyaBiomedical Research and Training Institute, Zimbabwe.
Tsitsi BandasonBiomedical Research and Training Institute, Zimbabwe.
Hilda MujuruDepartment of Paediatrics, University of Zimbabwe, Zimbabwe.
Joakim EsbjörnssonNuffield Department of Medicine, Oxford University, UK.
Rashida A FerrandBiomedical Research and Training Institute, Zimbabwe.
Sarah Rowland-JonesNuffield Department of Medicine, Oxford University, UK.
University of Oxford · GBBiomedical Research and Training Institute · ZWUniversity of Zimbabwe · ZW

Funding

Wellcome Trust 095878Wellcome Trust 095878/Z/11/ZWellcome Trust 206316/Z/17/Z
6 · The paper itself

Abstract

objectiveUntreated perinatal HIV-1 infection is often associated with rapid disease progression in children with HIV (CWH), characterized by high viral loads and early mortality. TRIM22 is a host restriction factor, which directly inhibits HIV-1 transcription, and its genotype variation is associated with disease progression in adults. We tested the hypothesis that TRIM22 genotype is associated with disease progression in CWH.

designART-naive CWH, aged 6-16 years, were recruited from primary care clinics in Harare, Zimbabwe. We performed a candidate gene association study of TRIM22 genotype and haplotypes with markers of disease progression and indicators of advanced disease.

methodsTRIM22 exons three and four were sequenced by Sanger sequencing and single nucleotide polymorphisms were associated with markers of disease progression (CD4+ T-cell count and HIV viral load) and clinical indicators of advanced HIV disease (presence of stunting and chronic diarrhoea). Associations were tested using multivariate linear and logistic regression models.

resultsA total of 241 children, median age 11.4 years, 50% female, were included. Stunting was present in 16% of participants. Five SNPs were analyzed including rs7935564, rs2291842, rs78484876, rs1063303 and rs61735273. The median CD4+ count was 342 (IQR: 195-533) cells/μl and median HIV-1 viral load 34 199 (IQR: 8211-90 662) IU/ml. TRIM22 genotype and haplotypes were not associated with CD4+ T-cell count, HIV-1 viral load, stunting or chronic diarrhoea.

conclusionTRIM22 genotype was not associated with markers of HIV disease progression markers or advanced disease in CWH.

Indexed as

HIV-1HIV InfectionsAdolescentCD4 Lymphocyte CountChildDisease ProgressionFemaleGenotypeHumansMaleMinor Histocompatibility AntigensRepressor ProteinsTripartite Motif ProteinsViral LoadZimbabweMinor Histocompatibility AntigensRepressor ProteinsTRIM22 protein, humanTripartite Motif Proteins

Identifiers

PMID34870928
PMCPMC7614957
OpenAlexW3195636420

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.