Evidence map›Paper›PMID 34870881›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D

Hunter S Sims, Pedro de Andrade Horn, Ryota Isshiki, Melissa Lim, Yan Xu, Robert H Grubbs, Mingji Dai

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Total Synthesis of (±)-Stemocurtisine via Catalytic Carbonylation.Journal of the American Chemical Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hunter S SimsDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Pedro de Andrade HornDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Ryota IsshikiDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Melissa LimDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Yan XuThe Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Robert H GrubbsThe Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0002-0057-7817
Mingji DaiDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-7956-6426

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Purdue Drug Discovery Training ProgramT32GM125620 · NIGMS · PURDUE UNIVERSITY · PI DYKHUIZEN, EMILY CARLA, WEI, ALEXANDER · 2019 to 2023
$891k
National Science Foundation 1625543National Science Foundation 2102022NCI NIH HHS P30 CA023168NIGMS NIH HHS T32 GM125620NIH HHS CA023168NIH HHS GM125620
6 · The paper itself

Abstract

A concise and stereoselective total synthesis of the clinically relevant tricyclic prostaglandin D

Indexed as

Prostaglandin D2CatalysisEstersMolecular StructureNickelPalladiumStereoisomerismEstersNickelPalladiumProstaglandin D2CarbonylationNickel catalysisOlefin metathesisProstaglandinsTotal synthesis

Identifiers

PMID34870881
PMCPMC8766936

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.