Evidence map›Paper›PMID 34870790›Full record

ArticlePain and therapy2022

Abuse-Deterrent Opioids: A Survey of Physician Beliefs, Behaviors, and Psychology.

Nabarun Dasgupta, John R Brown, Maryalice Nocera, Allison Lazard, Svetla Slavova, Patricia R Freeman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Strategies to prevent long-term opioid use following trauma: a Canadian practice survey.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nabarun DasguptaUNC CB 7505, 725 Martin Luther King Jr. Blvd., Chapel Hill, NC, 27599, USA. nab@unc.edu.ORCID http://orcid.org/0000-0002-4098-605X
John R BrownUNC CB 7505, 725 Martin Luther King Jr. Blvd., Chapel Hill, NC, 27599, USA.
Maryalice NoceraUNC CB 7505, 725 Martin Luther King Jr. Blvd., Chapel Hill, NC, 27599, USA.
Allison LazardUNC CB 7505, 725 Martin Luther King Jr. Blvd., Chapel Hill, NC, 27599, USA.
Svetla SlavovaUNC CB 7505, 725 Martin Luther King Jr. Blvd., Chapel Hill, NC, 27599, USA.
Patricia R FreemanUNC CB 7505, 725 Martin Luther King Jr. Blvd., Chapel Hill, NC, 27599, USA.
University of North Carolina Health Care · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
NCATS NIH HHS UL1 TR001998NIH National Center for Advancing Translational Sciences (US) UL1TR001998U.S. Food and Drug Administration HHSF223201810183C
6 · The paper itself

Abstract

objectiveEvaluate beliefs and behaviors pertaining to abuse-deterrent opioids (ADFs).

designSurvey in 2019 by invitation to all licensed physicians.

settingCommonwealth of Kentucky.

participants374 physicians.

methodsDescriptive statistics, and hypothesis test that early adopter prescribers would have greater endorsement of opioid risk management.

resultsOf all prescribers, 55% believed all opioid analgesics should have ADF requirements (15% were unsure); 74% supported mandating insurance coverage. Only one-third considered whether an opioid was ADF when prescribing, motivated by patient family diversion (94%) and societal supply reduction (88%). About half believed ADFs were equally effective in preventing abuse by intact swallowing, injection, chewing, snorting, smoking routes. Only 4% of OxyContin prescribers chose it primarily because of ADF properties. Instead, the most common reason (33%) was being started by another prescriber. A quarter of physicians chose not to prescribe ADFs because of heroin switching potential. Early adopters strongly believed ADFs were effective in reducing abuse (PR 3.2; 95% CI 1.5, 6.6) compared to mainstream physicians. Early-adopter risk-management practices more often included tools increasing agency and measurement: urine drug screens (PR 2.0; 1.3, 3.1), risk screening (PR 1.3; 0.94, 1.9). While nearly all respondents (96%) felt that opioid abuse was a problem in the community, only 57% believed it was a problem among patients in their practice. Attribution theory revealed an externalization of opioid abuse problems that deflected blame from patients on to family members.

conclusionsThe primary motivator for prescribing ADFs was preventing diversion by family members, not patient-level abuse concerns.

Indexed as

Abuse-deterrent formulations (ADF)Drug abuseEpidemiologyOpioidsPain managementSurvey

Identifiers

PMID34870790
PMCPMC8861217
OpenAlexW4200253148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.