Evidence map›Paper›PMID 34870727›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

[

Yuchun Wei, Kai Cheng, Zheng Fu, Jinsong Zheng, Zhengshuai Mu, Chenglong Zhao, Xiaoli Liu, Shijie Wang, Jinming Yu, Shuanghu Yuan

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Performance of [European radiology · 2024
    Pooled it
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  12. Relationship between PD-L1 expression and [European journal of nuclear medicine and molecular imaging · 2025
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  15. Evaluating the diagnostic value ofJapanese journal of radiology · 2025
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  16. [European journal of nuclear medicine and molecular imaging · 2025
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  17. Comparison of the diagnostic accuracy betweenJournal of thoracic disease · 2025
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  18. Frontiers in oncology · 2025
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  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yuchun Wei *Cheeloo College of Medicine, Shandong University, Jinan, China.
Kai Cheng *Department of PET/CT Center, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Zheng FuDepartment of PET/CT Center, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Jinsong ZhengDepartment of PET/CT Center, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Zhengshuai MuDepartment of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Chenglong ZhaoDepartment of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Xiaoli LiuCheeloo College of Medicine, Shandong University, Jinan, China.
Shijie WangShandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.
Jinming YuCheeloo College of Medicine, Shandong University, Jinan, China. sdyujinming@126.com.
Shuanghu YuanCheeloo College of Medicine, Shandong University, Jinan, China. yuanshuanghu@sina.com.ORCID http://orcid.org/0000-0002-3857-2800
Shandong Tumor Hospital · CNShandong University · CN

Funding

Major Scientific and Technological Innovation Projects of Shandong 2018YFJH0502National Natural Science Foundation of China 81372413National Natural Science Foundation of China 81627901National Natural Science Foundation of China 81872475National Natural Science Foundation of China 82030082the Academic Promotion Program of Shandong First Medical University 2019ZL002
6 · The paper itself

Abstract

purposeHeterogeneity is found in the tumor microenvironment among different pathological types of tumors. Radionuclide-labeled fibroblast-activation-protein inhibitor (FAPI), as an important tracer for non-invasive imaging of the tumor microenvironment, can be used to evaluate the expression of FAP in cancer-associated fibroblasts, macrophages, and tumor cells. Our aim was to explore the ability of [

methodsWe prospectively enrolled 61 patients with histopathologically proven primary lung cancer with metastases. PET/CT scanning was performed before any antitumor therapy and 1 h after injection of 235.10 ± 3.89 MBq of [

resultsSixty-one patients with adenocarcinoma (ADC, n = 30), squamous cell carcinoma (SCC, n = 17), and small cell lung cancer (SCLC, n = 14) were enrolled in this study, and 61 primary tumors and 199 metastases were evaluated. No difference in [

conclusion[

Indexed as

Lung NeoplasmsSmall Cell Lung CarcinomaGallium RadioisotopesHeterocyclic Compounds, 1-RingHumansPositron Emission Tomography Computed TomographyQuinolinesTumor Microenvironment1,4,7-triazacyclononane-N,N',N''-triacetic acid68Ga-FAPIGallium RadioisotopesHeterocyclic Compounds, 1-RingQuinolinesFAPIFibroblast activation proteinLung cancerPET/CT

Identifiers

PMID34870727
PMCPMC8940861
OpenAlexW4200439793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.