Evidence map›Paper›PMID 34870283›Full record

ArticleAI and ethics2022

No-boundary thinking: a viable solution to ethical data-driven AI in precision medicine.

Tayo Obafemi-Ajayi, Andy Perkins, Bindu Nanduri, Donald C Wunsch Ii, James A Foster, Joan Peckham

Open access · hybridAbstract read
In one paragraph

Article in AI and ethics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Tayo Obafemi-AjayiEngineering Program, Missouri State University, Springfield, MO USA.ORCID 0000-0002-0155-9733
Andy PerkinsDepartment of Computer Science and Engineering, Mississippi State University, Starkville, MS USA.
Bindu NanduriDepartment of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State University, Starkville, MS USA.
Donald C Wunsch IiElectrical & Computer Engineering Department, Missouri University of Science and Technology, Rolla, MO USA.
James A FosterBiological Sciences Department, University of Idaho, Moscow, ID USA.
Joan PeckhamComputer Science & Statistics Department, University of Rhode Island, Kingston, RI USA.
Mississippi State University · USMissouri State University · USMissouri University of Science and Technology · USUniversity of Idaho · USUniversity of Rhode Island · US

Funding

Zinc dependent conformational changes in AdcR and their impact on DNA bindingP20GM103646 · NIGMS · MISSISSIPPI STATE UNIVERSITY · PI THIBAUDEAU, GISELLE · 2013 to 2022
$21.1M
NIGMS NIH HHS P20 GM103646
6 · The paper itself

Abstract

Today Artificial Intelligence (AI) supports difficult decisions about policy, health, and our personal lives. The AI algorithms we develop and deploy to make sense of information, are informed by data, and based on models that capture and use pertinent details of the population or phenomenon being analyzed. For any application area, more importantly in precision medicine which directly impacts human lives, the data upon which algorithms are run must be procured, cleaned, and organized well to assure reliable and interpretable results, and to assure that they do not perpetrate or amplify human prejudices. This must be done without violating basic assumptions of the algorithms in use. Algorithmic results need to be clearly communicated to stakeholders and domain experts to enable sound conclusions. Our position is that AI holds great promise for supporting precision medicine, but we need to move forward with great care, with consideration for possible ethical implications. We make the case that a no-boundary or convergent approach is essential to support sound and ethical decisions. No-boundary thinking supports problem definition and solving with teams of experts possessing diverse perspectives. When dealing with AI and the data needed to use AI, there is a spectrum of activities that needs the attention of a no-boundary team. This is necessary if we are to draw viable conclusions and develop actions and policies based on the AI, the data, and the scientific foundations of the domain in question.

Indexed as

Artificial intelligenceData scienceEthicsPrecision medicine

Identifiers

PMID34870283
PMCPMC8628283
OpenAlexW3217527534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.