ArticleACS organic & inorganic Au2021
Covalent [2]Catenane and [2]Rotaxane Synthesis via a δ-Amino Acid Template.
Article in ACS organic & inorganic Au, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Covalent Templated Catenane Synthesis Requiring Hindered Ester Cleavage.The Journal of organic chemistry · 2026Article
- Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules.Chemical reviews · 2025Review
- Rotaxane nanomachines in future molecular electronics.Nanoscale advances · 2022Review
- Distinctive features and challenges in catenane chemistry.Chemical science · 2022Review
- Welcome to Volume 2 ofACS organic & inorganic Au · 2022Article
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Authors and funding
3 authors.
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Abstract
Despite the advances in the synthesis of mechanically interlocked molecules, a generally applicable approach to interlocked natural products, such as lasso peptides, is yet to be formulated. While amino acid sequences have been introduced into several rotaxanes, the key structural components have always been dictated by the method used for supramolecular preorganization. In this work, we report the use of an ester-functionalized, aromatic δ-amino acid as the central covalent templating unit in the synthesis of both a [2]catenane and a [2]rotaxane from the same multimacrocyclic intermediate. This represents a key step toward future synthetic peptide-based interlocked products.
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Registered trials
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