ArticleBrain communications2021
Implantable brain-computer interface for neuroprosthetic-enabled volitional hand grasp restoration in spinal cord injury.
Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Interim Safety Profile From the Feasibility Study of the BrainGate Neural Interface System.Neurology · 2023Trial
- Cyborg-swarm cooperation and game via affective-based brain-machine interface.National science review · 2026Article
- Motor Recovery After a Hemispherectomy: Review of Mechanisms and the Potential of Neuromodulation to Enhance Motor Outcomes.Journal of child neurology · 2026Review
- Reconnecting Minds to the World: Patient Perspectives on Brain-Computer Interface After High Cervical Spinal Cord Injury.Annals of rehabilitation medicine · 2026Article
- Optimal location for gesture decoding in the sensorimotor cortex and implications for brain-computer interface research.NeuroImage · 2026Article
- Iron-Responsive Deferasirox Release from Covalently Grafted Hydrogels on Microwires Extends Iron Chelation Time Scales.ACS applied materials & interfaces · 2026Article
- High-resolution cortical mapping within and across the central sulcus using 1024-electrode micro-electrocorticography arrays: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Classifying motion states from neural activity of non-human primates for brain-computer interfaces.Frontiers in neuroscience · 2026Article
- From deep brain stimulation to brain-computer interfaces: current progress in implantable neurotechnology.Frontiers in neuroscience · 2026Review
- Advances in Bionic Therapies for Targeting Neural Circuit Reconstruction and Integration for Spinal Cord Injury.Cellular and molecular neurobiology · 2025Review
- Technological Advances and Medical Applications of Implantable Electronic Devices: From the Heart, Brain, and Skin to Gastrointestinal Organs.Biosensors · 2025Review
- 5-year follow-up of a fully implanted brain-computer interface in a spinal cord injury patient.Journal of neural engineering · 2025Article
- Neural signal analysis in chronic stroke: advancing intracortical brain-computer interface design.Frontiers in human neuroscience · 2025Article
- Current and emergent therapies targeting spinal cord injury.Brain & spine · 2025Review
- Signal acquisition of brain-computer interfaces: A medical-engineering crossover perspective review.Fundamental research · 2025Review
- Motor imagery-based brain-computer interfaces: an exploration of multiclass motor imagery-based control for Emotiv EPOC X.Frontiers in neuroinformatics · 2025Article
- Enhancing neuroprosthesis calibration: the advantage of integrating prior training over exclusive use of new data.Journal of neural engineering · 2024Article
- The speech neuroprosthesis.Nature reviews. Neuroscience · 2024Review
- Neurotrauma-From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord.Biomedicines · 2024Review
- Propofol-mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.Journal of cognitive neuroscience · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
23 authors at 4 institutions in 2 countries.
Funding
Abstract
Loss of hand function after cervical spinal cord injury severely impairs functional independence. We describe a method for restoring volitional control of hand grasp in one 21-year-old male subject with complete cervical quadriplegia (C5 American Spinal Injury Association Impairment Scale A) using a portable fully implanted brain-computer interface within the home environment. The brain-computer interface consists of subdural surface electrodes placed over the dominant-hand motor cortex and connects to a transmitter implanted subcutaneously below the clavicle, which allows continuous reading of the electrocorticographic activity. Movement-intent was used to trigger functional electrical stimulation of the dominant hand during an initial 29-weeks laboratory study and subsequently via a mechanical hand orthosis during in-home use. Movement-intent information could be decoded consistently throughout the 29-weeks in-laboratory study with a mean accuracy of 89.0% (range 78-93.3%). Improvements were observed in both the speed and accuracy of various upper extremity tasks, including lifting small objects and transferring objects to specific targets. At-home decoding accuracy during open-loop trials reached an accuracy of 91.3% (range 80-98.95%) and an accuracy of 88.3% (range 77.6-95.5%) during closed-loop trials. Importantly, the temporal stability of both the functional outcomes and decoder metrics were not explored in this study. A fully implanted brain-computer interface can be safely used to reliably decode movement-intent from motor cortex, allowing for accurate volitional control of hand grasp.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.