Evidence map›Paper›PMID 34870131›Full record

ArticleiScience2021

A deep learning approach for predicting severity of COVID-19 patients using a parsimonious set of laboratory markers.

Vivek Singh, Rishikesan Kamaleswaran, Donald Chalfin, Antonio Buño-Soto, Janika San Roman, Edith Rojas-Kenney, Ross Molinaro, Sabine von Sengbusch, Parsa Hodjat, Dorin Comaniciu and 1 more

Abstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  13. Prediction of COVID-19 Patients' Survival by Deep Learning Approaches.Medical journal of the Islamic Republic of Iran · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vivek SinghSiemens Healthineers, Digital Technology and Innovation, 755 College Road East, Princeton, NJ 08540, USA.
Rishikesan KamaleswaranEmory University School of Medicine WMB, 1010 Woodruff Circle, Suite 4127, Atlanta, GA 30322, USA.
Donald ChalfinSiemens Healthineers, Laboratory Diagnostics, 511 Benedict Avenue, Tarrytown, NY 10591, USA.
Antonio Buño-SotoDepartment of Laboratory Medicine, Hospital Universitario La Paz, Madrid, Spain.
Janika San RomanSiemens Healthineers, Laboratory Diagnostics, 511 Benedict Avenue, Tarrytown, NY 10591, USA.
Edith Rojas-KenneySiemens Healthineers, Laboratory Diagnostics, 511 Benedict Avenue, Tarrytown, NY 10591, USA.
Ross MolinaroSiemens Healthineers, Laboratory Diagnostics, 511 Benedict Avenue, Tarrytown, NY 10591, USA.
Sabine von SengbuschSiemens Healthineers, Laboratory Diagnostics, 511 Benedict Avenue, Tarrytown, NY 10591, USA.
Parsa HodjatDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, 6565 Fannin Street, Houston, TX 77030, USA.
Dorin ComaniciuSiemens Healthineers, Digital Technology and Innovation, 755 College Road East, Princeton, NJ 08540, USA.
Ali KamenSiemens Healthineers, Digital Technology and Innovation, 755 College Road East, Princeton, NJ 08540, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 virus has caused tremendous healthcare burden worldwide. Our focus was to develop a practical and easy-to-deploy system to predict the severe manifestation of disease in patients with COVID-19 with an aim to assist clinicians in triage and treatment decisions. Our proposed predictive algorithm is a trained artificial intelligence-based network using 8,427 COVID-19 patient records from four healthcare systems. The model provides a severity risk score along with likelihoods of various clinical outcomes, namely ventilator use and mortality. The trained model using patient age and nine laboratory markers has the prediction accuracy with an area under the curve (AUC) of 0.78, 95% CI: 0.77-0.82, and the negative predictive value NPV of 0.86, 95% CI: 0.84-0.88 for the need to use a ventilator and has an accuracy with AUC of 0.85, 95% CI: 0.84-0.86, and the NPV of 0.94, 95% CI: 0.92-0.96 for predicting in-hospital 30-day mortality.

Indexed as

Artificial intelligenceClassification Description: VirologyDiagnosticsMachine learning

Identifiers

PMID34870131
PMCPMC8626152

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.