Evidence map›Paper›PMID 34870062›Full record

ArticleOTO open

Tumor-Associated Macrophages in Vestibular Schwannoma and Relationship to Hearing.

Eric Nisenbaum, Carly Misztal, Mikhaylo Szczupak, Torin Thielhelm, Stefanie Peña, Christine Mei, Stefania Goncalves, Olena Bracho, Ruixuan Ma, Michael E Ivan and 5 more

Open access · goldAbstract read
In one paragraph

Article in OTO open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Fimepinostat Promotes Apoptosis and Decreases Cytokine Secretion inInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Updates on Tumor Biology in Vestibular Schwannoma.Otolaryngologic clinics of North America · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. A Critical Overview of Targeted Therapies for Vestibular Schwannoma.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Eric NisenbaumDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID https://orcid.org/0000-0002-0744-2712
Carly MisztalDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Mikhaylo SzczupakDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Torin ThielhelmDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Stefanie PeñaDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Christine MeiDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Stefania GoncalvesDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Olena BrachoDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Ruixuan MaDepartment of Biostatistics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Michael E IvanDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Jacques MorcosDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Fred TelischiDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Xue-Zhong LiuDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Cristina Fernandez-ValleBurnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, USA.
Christine T DinhDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
University of Miami · USUniversity of Central Florida · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective(1) Characterize the distribution of M1 and M2 macrophages in vestibular schwannomas by hearing status. (2) Develop assays to assess monocyte migration and macrophage polarization in cocultures with vestibular schwannoma cells. STUDY

designBasic and translational science.

settingTertiary care center.

methodsA retrospective chart review of 30 patients with vestibular schwannoma (VS) was performed. Patients were stratified into serviceable and unserviceable hearing groups. Immunohistochemistry for CD80

resultsAlthough tumors associated with unserviceable hearing had higher levels of CD80 and CD163 than those with serviceable hearing, the relationship was only significant with CD163 (

conclusionVestibular schwannomas express varying degrees of CD80

Indexed as

CD163CD80HLTAMtumor-associated macrophagesvestibular schwannoma

Identifiers

PMID34870062
PMCPMC8638079
OpenAlexW3216329772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.