Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy.

Masao Nakayama, Hiroaki Akasaka, Eiichi Miyazaki, Yoshihiro Goto, Yuya Oki, Yosuke Kawate, Kenta Morita, Ryohei Sasaki

Abstract read

In one paragraph

Article in Physics and imaging in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masao NakayamaDivision of Radiation Therapy, Kita-Harima Medical Center, 926-250 Ichibacho, Ono, Hyogo 675-1392, Japan.

Hiroaki AkasakaDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuou-ku, Kobe, Hyogo 650-0017, Japan.

Eiichi MiyazakiDivision of Radiation Therapy, Kita-Harima Medical Center, 926-250 Ichibacho, Ono, Hyogo 675-1392, Japan.

Yoshihiro GotoDepartment of Radiology, Kita-Harima Medical Center, 926-250 Ichibacho, Ono, Hyogo 675-1392, Japan.

Yuya OkiDivision of Radiation Oncology, Kobe Minimally Invasive Cancer Center, 8-5-1 Minatojima-Nakamachi, Chuou-ku, Kobe, Hyogo 650-0046, Japan.

Yosuke KawateDivision of Radiation Oncology, Kobe Minimally Invasive Cancer Center, 8-5-1 Minatojima-Nakamachi, Chuou-ku, Kobe, Hyogo 650-0046, Japan.

Kenta MoritaDepartment of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodaicho, Nada-ku, Kobe, Hyogo 657-8501, Japan.

Ryohei SasakiDivision of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuou-ku, Kobe, Hyogo 650-0017, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different concentrations were acquired using IGRT modalities, including cone-beam computed tomography (CBCT). AuNPs induced strong contrast enhancement in kV energy CBCT images, whereas TiOxNPs at high concentrations showed weak but detectable changes. The results indicated that these NPs can be used to enhance IGRT images as well as dose enhancement for treatment purposes.

Indexed as

IGRTNanoparticlesTheranosticsTitanium peroxide

Identifiers

PMID34869923

DOI10.1016/j.phro.2021.11.003

PMCPMC8626564

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.