Evidence map›Paper›PMID 34869783›Full record

ArticleJournal of immunology research2021

A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease.

Friederike Ebner, Katja Lindner, Katharina Janek, Agathe Niewienda, Piotr H Malecki, Manfred S Weiss, Tara E Sutherland, Arnd Heuser, Anja A Kühl, Jürgen Zentek and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Modulation of the Immune Response by Nematode Derived Molecules.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
  5. The Immune Response to Nematode Infection.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Friederike Ebner *Institute of Immunology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-3485-4077
Katja Lindner *Institute of Immunology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
Katharina JanekCharité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Biochemistry, Shared Facility for Mass Spectrometry, Berlin, Germany.
Agathe NiewiendaCharité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Biochemistry, Shared Facility for Mass Spectrometry, Berlin, Germany.
Piotr H MaleckiMacromolecular Crystallography (HZB-MX), Helmholtz-Zentrum Berlin, Berlin, Germany.
Manfred S WeissMacromolecular Crystallography (HZB-MX), Helmholtz-Zentrum Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-2362-7047
Tara E SutherlandLydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Arnd HeuserMax Delbrück Center for Molecular Medicine (MDC), Pathophysiology Platform, Berlin, Germany.
Anja A KühlCharité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, iPATH.Berlin, Berlin, Germany.
Jürgen ZentekInstitute of Animal Nutrition, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
Andreas HofmannDepartment of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia.
Susanne HartmannInstitute of Immunology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0001-6846-0650
Freie Universität Berlin · DEHumboldt-Universität zu Berlin · DEHelmholtz-Zentrum Berlin für Materialien und Energie · DEManchester Academic Health Science Centre · GBMax Delbrück Center · DEThe University of Melbourne · AU

Funding

MRF_ MRF-009-0002-RG-SUTHE
6 · The paper itself

Abstract

Immunomodulation of airway hyperreactivity by excretory-secretory (ES) products of the first larval stage (L1) of the gastrointestinal nematode

Indexed as

AnimalsBronchoalveolar Lavage FluidChitinasesCrystallography, X-RayDisease Models, AnimalEosinophiliaFemaleHelminth ProteinsHost-Parasite InteractionsHumansImmunomodulating AgentsLungMacrophages, AlveolarMiceOvalbuminRespiratory HypersensitivityAMCase, mouseChitinasesHelminth ProteinsImmunomodulating AgentsOvalbumin

Identifiers

PMID34869783
PMCPMC8639245
OpenAlexW3215692388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.