ArticleFrontiers in nutrition2021
Long-Term Overconsumption of Fat and Sugar Causes a Partially Reversible Pre-inflammatory Bowel Disease State.
Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Consequences of Western and Mediterranean Diets' Nutrients on the Microbiota-Gut-Brain Axis.Nutrients · 2026Review
- Dietary Oxysterols Reprogram Hepatic Lipid Metabolism and Reshape the Gut Metabolome-Microbiome Interface.bioRxiv : the preprint server for biology · 2026Article
- The influence of ultra-processed foods on gut microbiome and inflammatory markers in schoolchildren from Northeastern Brazil.Journal of pediatric gastroenterology and nutrition · 2026Article
- Optimized murine HFpEF models for translational preclinical studies.ESC heart failure · 2026Article
- The epidemiology of inflammatory bowel disease: exploring the impacts of environmental factors.The Korean journal of internal medicine · 2026Review
- Effects and mechanism ofWorld journal of gastroenterology · 2026Article
- The role of dietary factors in the prevention and management of inflammatory bowel disease: a comprehensive review.Nutrition & metabolism · 2025Review
- Rectal Microbiomes and Serum Metabolomics Reveal Changes in Serum Antioxidant Status and Immune Responses of Dezhou Donkeys in Late Gestation to Parturition.Antioxidants (Basel, Switzerland) · 2025Article
- Review
- Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective.Nutrition journal · 2025Review
- Association between dietary index for gut microbiota and diarrhea among US adults: a cross-sectional analysis of NHANES 2005-2010.Frontiers in nutrition · 2025Article
- Nutritional psychology and inflammatory bowel disease: a narrative review of gut-brain axis interactions.Frontiers in nutrition · 2025Review
- The Key Nutrients in the Mediterranean Diet and Their Effects in Inflammatory Bowel Disease: A Narrative Review.Nutrients · 2024Review
- Gut microbiota causally impacts adrenal function: a two-sample mendelian randomization study.Scientific reports · 2024Article
- Nutritional Profile, Disease Severity, and Quality of Life of Patients with Inflammatory Bowel Disease: A Case-Control Study.Nutrients · 2024Article
- Progress and Clinical Applications of Crohn's Disease Exclusion Diet in Crohn's Disease.Gut and liver · 2024Review
- Social demographics determinants for resistome and microbiome variation of a multiethnic community in Southern Malaysia.NPJ biofilms and microbiomes · 2023Article
- Intestinal cell type-specific communication networks underlie homeostasis and response to Western diet.The Journal of experimental medicine · 2023Article
- Sucrose-induced hyperglycemia dysregulates intestinal zinc metabolism and integrity: risk factors for chronic diseases.Frontiers in nutrition · 2023Article
- Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer's disease mouse model.Frontiers in cellular neuroscience · 2023Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutrition appears to be an important environmental factor involved in the onset of inflammatory bowel diseases (IBD) through yet poorly understood biological mechanisms. Most studies focused on fat content in high caloric diets, while refined sugars represent up to 40% of caloric intake within industrialized countries and contribute to the growing epidemics of inflammatory diseases. Herein we aim to better understand the impact of a high-fat-high-sucrose diet on intestinal homeostasis in healthy conditions and the subsequent colitis risk. We investigated the early events and the potential reversibility of high caloric diet-induced damage in mice before experimental colitis. C57BL/6 mice were fed with a high-fat or high-fat high-sucrose or control diet before experimental colitis. In healthy mice, a high-fat high-sucrose diet induces a pre-IBD state characterized by gut microbiota dysbiosis with a total depletion of bacteria belonging to Barnesiella that is associated with subclinical endoscopic lesions. An overall down-regulation of the colonic transcriptome converged with broadly decreased immune cell populations in the mesenteric lymph nodes leading to the inability to respond to tissue injury. Such
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.