Evidence map›Paper›PMID 34869521›Full record

ArticleFrontiers in nutrition2021

Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease.

Kaitlin Day, Lucia A Seale, Ross M Graham, Barbara R Cardoso

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

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  17. "Alphabet" Selenoproteins: Implications in Pathology.International journal of molecular sciences · 2023
    Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Kaitlin DayDepartment of Nutrition, Dietetics, and Food, Monash University, Notting Hill, VIC, Australia.
Lucia A SealePacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii, Honolulu, HI, United States.
Ross M GrahamCurtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.
Barbara R CardosoDepartment of Nutrition, Dietetics, and Food, Monash University, Notting Hill, VIC, Australia.
Monash University · AUCurtin University · AUPacific Biosciences (United States) · US

Funding

Selenium metabolism in cold-induced adaptive thermogenesisR01DK128390 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI SEALE, LUCIA ANDREIA · 2021 to 2025
$2.0M
NIDDK NIH HHS R01 DK128390
6 · The paper itself

Abstract

Observational studies indicate that selenium may contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Transcriptomic exploration of the aetiology and progression of NAFLD may offer insight into the role selenium plays in this disease. This study compared gene expression levels of known selenoprotein pathways between individuals with a healthy liver to those with NAFLD. Publicly available gene expression databases were searched for studies that measured global gene expression in liver samples from patients with steatosis and non-alcoholic steatohepatitis (NASH) and healthy controls (with [HOC] or without [HC] obesity). A subset of five selenoprotein-related pathways (164 genes) were assessed in the four datasets included in this analysis. The gene

Indexed as

ferroptosisnon-alcoholic steatohepatitisseleniumselenocysteine lyaseselenoproteins

Identifiers

PMID34869521
PMCPMC8635790
OpenAlexW3212103417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.