Evidence map›Paper›PMID 34869380›Full record

ArticleFrontiers in cell and developmental biology2021

Human Sperm Remain Motile After a Temporary Energy Restriction but do Not Undergo Capacitation-Related Events.

Clara I Marín-Briggiler, Guillermina M Luque, María G Gervasi, Natalia Oscoz-Susino, Jessica M Sierra, Carolina Mondillo, Ana M Salicioni, Darío Krapf, Pablo E Visconti, Mariano G Buffone

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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  8. Adenylate kinase 9 is essential for sperm function and male fertility in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Clara I Marín-BriggilerInstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina.
Guillermina M LuqueInstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina.
María G GervasiDepartment of Veterinary and Animal Science, University of Massachusetts, Amherst, MA, United States.
Natalia Oscoz-SusinoInstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina.
Jessica M SierraInstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina.
Carolina MondilloInstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina.
Ana M SalicioniDepartment of Veterinary and Animal Science, University of Massachusetts, Amherst, MA, United States.
Darío KrapfInstituto de Biología Molecular y Celular de Rosario (CONICET-UNR), Rosario, Argentina.
Pablo E ViscontiDepartment of Veterinary and Animal Science, University of Massachusetts, Amherst, MA, United States.
Mariano G BuffoneInstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARExperimental Medicine and Biology Institute · ARUniversity of Massachusetts Amherst · USInstituto de Biología Molecular y Celular de Rosario · AR

Funding

Sperm Ca2+ Signaling and Energy Pathways in basic science and ARTR01HD038082 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI VISCONTI, PABLO E. · 2000 to 2025
$6.5M
Crosstalk between metabolic and signaling pathways involved in sperm capacitationR01HD088571 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI JOCHEN BUCK, LONNY R LEVIN · 2017 to 2026
$6.1M
NICHD NIH HHS R01 HD038082NICHD NIH HHS R01 HD088571
6 · The paper itself

Abstract

To acquire fertilization competence, mammalian sperm must undergo several biochemical and physiological modifications known as capacitation. Despite its relevance, the metabolic pathways that regulate the capacitation-related events, including the development of hyperactivated motility, are still poorly described. Previous studies from our group have shown that temporary energy restriction in mouse sperm enhanced hyperactivation,

Indexed as

ATPcapacitationglucoseglycolysismetabolismoxidative phosphorylationpyruvate/lactatesperm motility

Identifiers

PMID34869380
PMCPMC8633110
OpenAlexW3214327839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.