Evidence map›Paper›PMID 34869374›Full record

ArticleFrontiers in cell and developmental biology2021

Methylation and Expression of Mutant

T Hartung, M Rhein, N Kalmbach, N Thau-Habermann, M Naujock, L Müschen, H Frieling, J Sterneckert, A Hermann, F Wegner and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Molecular hallmarks of ageing in amyotrophic lateral sclerosis.Cellular and molecular life sciences : CMLS · 2024
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

T HartungDepartment of Neurology, Hannover Medical School, Hannover, Germany.
M RheinDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hanover Medical School, Hanover, Germany.
N KalmbachDepartment of Neurology, Hannover Medical School, Hannover, Germany.
N Thau-HabermannDepartment of Neurology, Hannover Medical School, Hannover, Germany.
M NaujockDepartment of Neurology, Hannover Medical School, Hannover, Germany.
L MüschenDepartment of Neurology, Hannover Medical School, Hannover, Germany.
H FrielingDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hanover Medical School, Hanover, Germany.
J SterneckertCenter for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.
A HermannTranslational Neurodegeneration Section "Albrecht Kossel", Department of Neurology and Center for Transdisciplinary Neuroscience (CTNR), University Medical Center Rostock, University of Rostock, Rostock, Germany.
F WegnerDepartment of Neurology, Hannover Medical School, Hannover, Germany.
S PetriDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DETU Dresden · DEUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease leading to degeneration of motor neurons (MNs). Epigenetic modification of gene expression is increasingly recognized as potential disease mechanism. In the present study we generated motor neurons from induced pluripotent stem cells from ALS patients carrying a mutation in the fused in sarcoma gene (FUS) and analyzed expression and promoter methylation of the FUS gene and expression of DNA methyltransferases (

Indexed as

amyotrophic lateral sclerosisDNA methyltransferasesFUSinduced pluripotent stem cells derived motor neuronsmethylation

Identifiers

PMID34869374
PMCPMC8640347
OpenAlexW3215717398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.