Evidence map›Paper›PMID 34869280›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Improvements in Smartphone and Night Vision Imaging Technologies Enable Low Cost, On-Site Assays of Bioluminescent Cells.

Mark Wienhold, Andrew Kirkpatrick, Tingting Xu, Steven Ripp, Gary Sayler, Dan Close

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mark Wienhold490 BioTech, Inc., Knoxville, TN, United States.
Andrew Kirkpatrick490 BioTech, Inc., Knoxville, TN, United States.
Tingting XuCenter for Environmental Biotechnology, The University of Tennessee, Knoxville, TN, United States.
Steven Ripp490 BioTech, Inc., Knoxville, TN, United States.
Gary Sayler490 BioTech, Inc., Knoxville, TN, United States.
Dan Close490 BioTech, Inc., Knoxville, TN, United States.
490 BioTech (United States) · USUniversity of Tennessee at Knoxville · US

Funding

Development of a high-throughput screen to detect the effects of both pre- and post-biotransformed compounds for enhanced content drug discovery workflowsR44GM112241 · NIGMS · 490 BIOTECH, INC. · PI SAYLER, GARY S · 2017 to 2018
$997k
Expressing bacterial bioluminescence in human cell lines: Engineering autobioluminescent reporter cells to screen for endocrine disruptor chemicalsR44ES022567 · NIEHS · 490 BIOTECH, INC. · PI MORRISON, DAN · 2015 to 2016
$996k
Expressing humanized bacterial luciferase in stem cells: Moving beyond fireflyluciferase to expand the informational capacity of animal models for regenerativemedicineR42GM116622 · NIGMS · 490 BIOTECH, INC. · PI MORRISON, DAN · 2017 to 2018
$994k
Expanding the throughput of real-time toxicological screening of cardiac differentiation by expressing a synthetic luciferase/luciferin genetic pathway in iPSCsR44ES026269 · NIEHS · 490 BIOTECH, INC. · PI MORRISON, DAN · 2019 to 2020
$991k
Autonomously-activating bioluminescent reporters to enable continuous, real-time, non-invasive brain cell imagingR43MH118186 · NIMH · 490 BIOTECH, INC. · PI SAYLER, GARY S · 2018 to 2018
$150k
NIEHS NIH HHS R44 ES022567NIEHS NIH HHS R44 ES026269NIGMS NIH HHS R42 GM116622NIGMS NIH HHS R44 GM112241NIMH NIH HHS R43 MH118186
6 · The paper itself

Abstract

Technologies enabling on-site environmental detection or medical diagnostics in resource-limited settings have a strong disruptive potential compared to current analytical approaches that require trained personnel in laboratories with immobile, resource intensive instrumentation. Handheld devices, such as smartphones, are now routinely produced with CPUs, RAM, wireless data transfer capabilities, and high-resolution complementary metal oxide semiconductor (CMOS) cameras capable of supporting the capture and processing of bioluminescent signals. In theory, combining the capabilities of these devices with continuously bioluminescent human cell-based bioreporters would allow them to replicate the functionality of more expensive, more complex, and less flexible platforms while supporting human-relevant conclusions. In this work, we compare the performance of smartphone (CMOS) and night vision (image intensifier) devices with

Indexed as

bioluminescenceluciferaseoptical imagingportable analytical deviceremote sensingsmartphonetoxicity

Identifiers

PMID34869280
PMCPMC8640239
OpenAlexW3215317558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.