Evidence map›Paper›PMID 34869270›Full record

ArticleFrontiers in bioengineering and biotechnology2021

A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds.

Yifan Yuan, Katherine L Leiby, Allison M Greaney, Micha Sam Brickman Raredon, Hong Qian, Jonas C Schupp, Alexander J Engler, Pavlina Baevova, Taylor S Adams, Mehmet H Kural and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Clinical Translation of Engineered Pulmonary Vascular Models.Advances in experimental medicine and biology · 2023
    Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Yifan YuanVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Katherine L LeibyVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Allison M GreaneyVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Micha Sam Brickman RaredonVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Hong QianVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Jonas C SchuppSection of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.
Alexander J EnglerVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Pavlina BaevovaVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Taylor S AdamsSection of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.
Mehmet H KuralVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Juan WangVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Tomohiro ObataVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Mervin C YoderIndiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, United States.
Naftali KaminskiSection of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT, United States.
Laura E NiklasonVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, United States.
Yale University · USIndiana University – Purdue University Indianapolis · USMedizinische Hochschule Hannover · DE

Funding

Biologically Selective Drug-Eluting StentR01HL148819 · NHLBI · YALE UNIVERSITY · PI SALTZMAN, WILLIAM · 2019 to 2022
$2.7M
NHLBI NIH HHS R01 HL148819
6 · The paper itself

Abstract

The development of an

Indexed as

endotheliumin vitro disease modelingpulmonary vasculaturesingle-cell RNA-sequencingwhole lung tissue engineering

Identifiers

PMID34869270
PMCPMC8640093
OpenAlexW3214736829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.