ArticleFrontiers in pediatrics2021
Case Report: Newborns With Pseudohypoaldosteronism Secondary to Excessive Gastrointestinal Losses Through High Output Stoma.
Article in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Secondary hyperaldosteronism associated with severe infantile atopic dermatitis: a case series.Annals of pediatric endocrinology & metabolism · 2026Article
- Diagnostic Challenges in Severe Electrolyte Imbalance in Early Infancy: A Case Report of Secondary Pseudohypoaldosteronism.Pediatric reports · 2026Article
- Hyponatremia in babies: a 11-year single-center study.Frontiers in pediatrics · 2024Article
- Aldosterone defects in infants and young children with hyperkalemia: A single center retrospective study.Frontiers in pediatrics · 2023Article
- Case report: Life threatening hyponatremia in infants with urinary tract infections: two cases of type III pseudohypoaldosteronism and review of the literature.Frontiers in pediatrics · 2023Article
- Neonatal Pseudohypoaldosteronism Type-1 in Japan.Journal of clinical medicine · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Life-threatening electrolyte imbalance is not uncommon in preemies. Differential diagnosis is important for immediate treatment. The syndrome of pseudohypoaldosteronism (PHA) is characterized by increased aldosterone secretion associated with clinical signs of hypoaldosteronism reflecting mineralocorticoid resistance. There are type I, type II, and secondary type of PHA. Most secondary PHA reported in the pediatric population result from urinary infection and obstructive uropathy and extremely rarely from gastrointestinal fluid loss. Seven preemies accepted jejunostomy or ileostomy, and they suffered from high output stoma. Electrolyte imbalance with bodyweight loss or cardiac event was noted. We found a high level of aldosterone and renin and diagnosed them with secondary PHA due to excessive gastrointestinal losses. After stomal reversal, aldosterone and renin level became normalized, and electrolyte was corrected. This study reports the finding of secondary pseudohyperaldosteronism (hyponatremia, hyperkalemia, and metabolic acidosis) in a series of cases with intestinal resection and ostomy of different causes. Early stomal reversal was recommended.
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