Evidence map›Paper›PMID 34869080›Full record

ArticleFrontiers in cellular and infection microbiology2021

Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder.

Di Deng, Hang Su, Yuehong Song, Tianzhen Chen, Qianqian Sun, Haifeng Jiang, Min Zhao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 24 citations in OpenAlex.

  1. GutGut microbes · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Di DengShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hang SuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuehong SongShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tianzhen ChenShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qianqian SunShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haifeng JiangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Min ZhaoShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Jiao Tong University · CNShanghai Mental Health Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methamphetamine use disorder (MUD) is a major public health problem worldwide with limited effective treatment options. Previous studies have reported methamphetamine-associated alterations in gut microbiota. A potential role of gut microbiota in regulating methamphetamine-induced brain dysfunction through interactions with the host immune system has been proposed, but evidence for this hypothesis is limited. The present study aimed to investigate the alterations in the fecal microbiota and explore its relationship with systemic inflammation in MUD. Fecal samples were obtained from 26 male subjects with MUD and 17 sex- and age- matched healthy controls. Fecal microbial profiles were analyzed by 16S rRNA sequencing. Plasma inflammatory markers were measured using enzyme-linked immunosorbent assay. Associations between fecal microbiota, systemic inflammatory markers and clinical characteristics were examined by Spearman partial correlation analysis while controlling for possible confounders. Compared with healthy controls, individuals with MUD showed no difference in fecal microbial diversity, but exhibited differences in the relative abundance of several microbial taxa. At the genus level, a higher abundance of

Indexed as

Gastrointestinal MicrobiomeMethamphetamineMicrobiotaFecesHumansInflammationMaleRNA, Ribosomal, 16SMethamphetamineRNA, Ribosomal, 16S16S rRNA sequencegut-immune-braingut microbiotamethamphetamine use disordersystemic inflammation

Identifiers

PMID34869080
PMCPMC8637621
OpenAlexW3211562355

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.