Evidence map›Paper›PMID 34868770›Full record

ArticleCureus2021

Light-Chain Multiple Myeloma: A Diagnostic Challenge.

Cristina Silva, Ana Costa, David Paiva, Sara Freitas, Glória Alves, Jorge Cotter

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Plasmablastic myeloma transformation of light-chain multiple myeloma.Journal of clinical and experimental hematopathology : JCEH · 2024
    Article
  7. Article
  8. Light-Chain Myeloma Presented as Osseus Tumors: A Case Report.Journal of investigative medicine high impact case reports
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cristina SilvaInternal Medicine, Hospital Senhora da Oliveira, Guimarães, PRT.
Ana CostaInternal Medicine, Hospital Senhora da Oliveira, Guimarães, PRT.
David PaivaInternal Medicine, Hospital Senhora da Oliveira, Guimarães, PRT.
Sara FreitasInternal Medicine, Hospital Senhora da Oliveira, Guimarães, PRT.
Glória AlvesInternal Medicine, Hospital Senhora da Oliveira, Guimarães, PRT.
Jorge CotterInternal Medicine, Hospital Senhora da Oliveira, Guimarães, PRT.
Hospital da Senhora da Oliveira Guimarães · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Light-chain multiple myeloma (LCMM) is a less frequent type of multiple myeloma (MM), with a more aggressive course and poorer prognosis. It is characterized by the inability of the malignant plasma cells to produce heavy chains, resulting in the exclusive production of light chains. Therefore, no M-spike is visible in serum protein electrophoresis. We described the case of a 67-year-old female who presents to the emergency department with anemia, severe renal insufficiency, and multiple lytic bone lesions. After three days, the diagnosis of kappa light chain multiple myeloma was made in a patient with elevated serum and urinary kappa light chains and a bone marrow aspirate with 21.7% of atypical plasma cells. The rapid diagnosis allowed prompt referral to a specialized multiple myeloma center and early initiation of treatment.

Indexed as

anemiafree light chainslytic bone lesionmultiple myelomarenal insufficiency

Identifiers

PMID34868770
PMCPMC8627691
OpenAlexW3210661949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.