Evidence map›Paper›PMID 34868668›Full record

ArticleOman medical journal2021

Cognitive Function in Adults with Beta-Thalassemia Major in Oman: A Pilot Study.

Shahina Daar, Muna Al Saadoon, Yasser Wali, Rawan Al Mujaini, Sarah Al Rahbi, Moon Fai Chan, Alya Al-Siyabi, Niveen Alansary, Sangeetha Mahadevan, Samir Al-Adawi

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Article in Oman medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shahina DaarDepartment of Hematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Muna Al SaadoonDepartment of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Yasser WaliDepartment of Child Health, Pediatric Hematology, Oncology and Hematopoietic Stem Cell Transplant Unit, Sultan Qaboos University Hospital, Muscat, Oman.
Rawan Al MujainiDepartment of Behavioral Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Sarah Al RahbiDepartment of Hematology, Sultan Qaboos University Hospital, Muscat, Oman.
Moon Fai ChanDepartment of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Alya Al-SiyabiDepartment of Child Health, Sultan Qaboos University Hospital, Muscat, Oman.
Niveen AlansaryDepartment of Hematology, Sultan Qaboos University Hospital, Muscat, Oman.
Sangeetha MahadevanDepartment of Behavioral Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Samir Al-AdawiDepartment of Behavioral Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNeurocognitive dysfunction has been established in several studies in children with beta-thalassemia major (TM). However, despite its wide occurrence in populations across the Arabian Peninsula, scant attention has been paid to shedding light on neuropsychological functioning among adults with TM. This study aimed to examine the level of neuropsychological functioning among Omani adults with TM regularly followed-up at a tertiary care hospital in Oman. A related aim was to examine the factors associated with neuropsychological performance.

methodsStandard neuropsychological tests were used to measure attention and concentration, learning and remembering, verbal fluency, and executive functioning. Participants were also gauged on indices of intellectual ability and affective range. As normative data for neuropsychological functioning in Oman is scarce, healthy age- and sex-matched controls underwent the same testing procedure. The log-linear model was used to identify factors associated with TM patients on demographic and neuropsychological performance.

resultsThis study recruited 28 adult patients with TM (age 30.0±6.5) and 39 healthy controls (age 29.2±6.1). Findings suggested that having a diagnosis of TM was significantly associated with symptoms of depression (

conclusionsThe data appears to suggest that short-term memory capacity, verbal fluency, and verbal and auditory attention may be impaired in TM compared to controls. Studies on a larger cohort are therefore warranted.

Indexed as

AnxietyB-ThalassemiaCognitionDepressionExecutive FunctionMemory, Short-TermNeuropsychological TestsOman

Identifiers

PMID34868668
PMCPMC8630422

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.