Evidence map›Paper›PMID 34868630›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical2021

Evaluation of short-term safety of COVID-19 vaccines in patients with multiple sclerosis from Latin America.

Ricardo Alonso, Aníbal Chertcoff, Felisa Del V Leguizamón, Lorna Galleguillos Goiry, Maria B Eizaguirre, Roberto Rodríguez, Marta Sosa, Susana Carballido, Verónica Cruchet, Agnes de Jong-Martis and 6 more

Open access · goldAbstract read
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  7. Progressive multifocal leukoencephalopathy or severe multiple sclerosis relapse following COVID-19 vaccine: a diagnostic challenge.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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  9. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Ricardo AlonsoCentro Universitario de Esclerosis Múltiple - CUEM, Hospital Ramos Mejía, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0001-9955-8343
Aníbal ChertcoffEsclerosis Múltiple Argentina - EMA, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-8645-6134
Felisa Del V LeguizamónHospital Británico, Buenos Aires, Argentina.
Lorna Galleguillos GoiryHospital Álvarez, Buenos Aires, Argentina.
Maria B EizaguirreCentro Universitario de Esclerosis Múltiple - CUEM, Hospital Ramos Mejía, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-7817-2772
Roberto RodríguezClínica Alemana, Santiago de Chile, Chile.
Marta SosaRenacer, Fundación Dominicana de EM, Santo Domingo, Dominican Republic.
Susana CarballidoAsociación de Lucha contra la Esclerosis Múltiple de Colombia - ALEM, Medellín, Colombia.
Verónica CruchetEsclerosis Múltiple Uruguay - EMUR, Montevideo, Uruguay.
Agnes de Jong-MartisCorporación Esclerosis Múltiple Chile, Santiago de Chile, Chile.
Susana GiachelloStichting Multiple Sclerose Curacao, Willemstad, Curacao.
Paula HenestrozaStichting Multiple Sclerose Curacao, Willemstad, Curacao.
Flavia FerrandinaAsociacion de Lucha contra la Esclerosis Múltiple - ALCEM, San Antonio de Padua, Argentina.
Johana BauerAsociacion de Lucha contra la Esclerosis Múltiple - ALCEM, San Antonio de Padua, Argentina.
Adriana CarráEsclerosis Múltiple Argentina - EMA, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0003-3874-4884
Berenice A SilvaCentro Universitario de Esclerosis Múltiple - CUEM, Hospital Ramos Mejía, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0001-5866-2419
Hospital Ramos Mejía · ARUniversity of Curaçao · CWClínica Alemana · CLHospital Británico de Buenos Aires · ARHospital General de Agudos Dr. TEODORO ALVAREZ · ARInstituto Nacional de Diabetes, Endocrinología y Nutrición · DOProduction Development Corporation · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo date, there are no data available on the safety of COVID-19 vaccines in Latin American patients with Multiple Sclerosis (MS).

objectiveCharacterize safety of COVID-19 vaccines in Latin American (LATAM) patients with Multiple Sclerosis (pwMS).

methodsA cross-sectional study between February 1, 2021, and April 30, 2021. Individuals with MS from LATAM countries were invited to participate in a self-administered web-based survey, through MS patient organizations from the region.

results393 vaccinated pwMS from 10 different Latin American countries were included. The vaccines administered were: inactivated virus vaccines (IVV) in 38.2% of patients, adenovirus vector vaccines (AdV) in 48.8% and mRNA vaccines 13%. All patients received at least one dose of any of the COVID-19 vaccines and 123 (31.3%) declared receiving a second dose. Mean (SD) age 41.5 (11.8) years, 82.4% female, MS disease duration: 8.4 (8.2) years. No serious adverse events were reported with any of the COVID-19 vaccines after either the first or second dose. A lower frequency of adverse events was found with IVV (22%) in comparison with AdV (46.4%) and mRNA (35.3%) (

conclusionCOVID-19 vaccines applied in LATAM proved safe for MS patients.

Indexed as

COVID-19Multiple sclerosissafetyvaccines

Identifiers

PMID34868630
PMCPMC8637726
OpenAlexW3216795126

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.