Evidence map›Paper›PMID 34868541›Full record

ReviewJournal of tissue engineering

Advanced bioengineering of male germ stem cells to preserve fertility.

Hossein Eyni, Sadegh Ghorbani, Hojjatollah Nazari, Marziyeh Hajialyani, Sajad Razavi Bazaz, Mahdi Mohaqiq, Majid Ebrahimi Warkiani, Duncan S Sutherland

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Hossein EyniDepartment of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Sadegh GhorbaniInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-9591-7721
Hojjatollah NazariResearch Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Marziyeh HajialyaniPharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Sajad Razavi BazazSchool of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia.
Mahdi MohaqiqInstitute of Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Majid Ebrahimi WarkianiSchool of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia.
Duncan S SutherlandInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark.
Aarhus University · DKUniversity of Technology Sydney · AUKermanshah University of Medical Sciences · IRTarbiat Modares University · IRTehran University of Medical Sciences · IRWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In modern life, several factors such as genetics, exposure to toxins, and aging have resulted in significant levels of male infertility, estimated to be approximately 18% worldwide. In response, substantial progress has been made to improve in vitro fertilization treatments (e.g. microsurgical testicular sperm extraction (m-TESE), intra-cytoplasmic sperm injection (ICSI), and round spermatid injection (ROSI)). Mimicking the structure of testicular natural extracellular matrices (ECM) outside of the body is one clear route toward complete in vitro spermatogenesis and male fertility preservation. Here, a new wave of technological innovations is underway applying regenerative medicine strategies to cell-tissue culture on natural or synthetic scaffolds supplemented with bioactive factors. The emergence of advanced bioengineered systems suggests new hope for male fertility preservation through development of functional male germ cells. To date, few studies aimed at in vitro spermatogenesis have resulted in relevant numbers of mature gametes. However, a substantial body of knowledge on conditions that are required to maintain and mature male germ cells in vitro is now in place. This review focuses on advanced bioengineering methods such as microfluidic systems, bio-fabricated scaffolds, and 3D organ culture applied to the germline for fertility preservation through in vitro spermatogenesis.

Indexed as

advanced tissue engineeringbiomaterialsin vitro spermatogenesisMale germ cellsmale reproductive systemmale reproductive tissue engineeringstem cells

Identifiers

PMID34868541
PMCPMC8638075
OpenAlexW3217296584

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.