Highly Reliable Method to Obtain a Correlation Coefficient Unaffected by the SEM Noise Component for Examining the Degree of Specimen Damage due to Electron Beam Irradiation.

A correlation coefficient is often used as a measure of the strength of a linear relationship (i.e., the degree of similarity) between two sets of data in a variety of fields. However, in the field of scanning electron microscopy (SEM), it is frequently difficult to properly use the correlation coefficient because SEM images generally include severe noise, which affects the measurement of this coefficient. The current study describes a method of obtaining a correlation coefficient that is unaffected by SEM noise in principle. This correlation coefficient is obtained from a total of four SEM images, comprising two sets of two images with identical views, by calculating several covariance values. Numerical experiments confirm that the measured correlation coefficients obtained using the proposed method for noisy images are equal to those for noise-free images. Furthermore, the present method can be combined with a highly accurate and noise-robust position alignment as needed. As one application, we show that it is possible to immediately examine the degree of specimen damage due to electron beam irradiation during a certain SEM observation, which has been difficult until now.