Evidence map›Paper›PMID 34868039›Full record

ArticleFrontiers in immunology2021

Hanqi Lu, Yanting You, Xinghong Zhou, Qiuxing He, Ming Wang, Liqian Chen, Lin Zhou, Xiaomin Sun, Yanyan Liu, Pingping Jiang and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
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  3. Article
  4. Article
  5. Article
  6. Article
  7. Frontiers in microbiology · 2025
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  9. A probiotic for preventing microplastic toxicity:Current research in food science · 2025
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  10. Food chemistry: X · 2024
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  11. Nutrients · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Frontiers in microbiology · 2022
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Hanqi LuDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Yanting YouDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Xinghong ZhouDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Qiuxing HeDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Ming WangDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Liqian ChenSchool of Chinese Medicine, Southern Medical University, Guangzhou, China.
Lin ZhouEndocrinology Department, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaomin SunSchool of Chinese Medicine, Southern Medical University, Guangzhou, China.
Yanyan LiuSchool of Chinese Medicine, Southern Medical University, Guangzhou, China.
Pingping JiangSchool of Chinese Medicine, Southern Medical University, Guangzhou, China.
Jiaojiao DaiSchool of Chinese Medicine, Southern Medical University, Guangzhou, China.
Xiuqiong FuSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, China.
Hiu Yee KwanSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, China.
Xiaoshan ZhaoDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Linjie LouThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Southern Medical University · CNZhujiang Hospital · CNHong Kong Baptist University · HKWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Studies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism disorder in adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process. Purpose: The study investigated whether early-life azithromycin (AZT) exposure in mice could promote high-fat diet (HFD)-induced glycolipid metabolism disorder in adulthood. Moreover, the effect of citrus reticulata pericarpium (CRP) extract on glycolipid metabolism disorder Methods and Results: Three-week-old mice were treated with AZT (50 mg/kg/day) Conclusion: Taken together, these findings suggest that early-life AZT exposure increases the susceptibility to HFD-induced glycolipid metabolism disorder in adult mice, and CRP extract can decrease this susceptibility by regulating gut microbiome.

Indexed as

AnimalsAnti-Bacterial AgentsAzithromycinBiomarkersChromatography, High Pressure LiquidCitrusDiet, High-FatDisease Models, AnimalDisease SusceptibilityGlucose Tolerance TestGlycolipidsInflammation MediatorsLipid MetabolismMaleMetabolic DiseasesMiceAnti-Bacterial AgentsAzithromycinBiomarkersGlycolipidsInflammation MediatorsPlant Extractsantibiotic exposureCitrus reticulata pericarpium extractearly lifeglycolipid metabolism disorderTMAO

Identifiers

PMID34868039
PMCPMC8640250
OpenAlexW3215661468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.