Evidence map›Paper›PMID 34868015›Full record

ArticleFrontiers in immunology2021

Development of a Flow Cytometry Assay to Predict Immune Checkpoint Blockade-Related Complications.

Hannah-Lou Schilling, Gunther Glehr, Michael Kapinsky, Norbert Ahrens, Paloma Riquelme, Laura Cordero, Florian Bitterer, Hans J Schlitt, Edward K Geissler, Sebastian Haferkamp and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Applications of Flow Cytometry in Drug Discovery and Translational Research.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Hannah-Lou SchillingDepartment of Surgery, University Hospital Regensburg, Regensburg, Germany.
Gunther GlehrInstitute of Functional Genomics and Statistical Bioinformatics, University of Regensburg, Regensburg, Germany.
Michael KapinskyBeckman Coulter Germany, Krefeld, Germany.
Norbert AhrensMedizinisches Versorgungszentrum (MVZ) for Laboratory Medicine Raubling, amedes Labor, Raubling, Germany.
Paloma RiquelmeDepartment of Surgery, University Hospital Regensburg, Regensburg, Germany.
Laura CorderoDepartment of Surgery, University Hospital Regensburg, Regensburg, Germany.
Florian BittererDepartment of Surgery, University Hospital Regensburg, Regensburg, Germany.
Hans J SchlittDepartment of Surgery, University Hospital Regensburg, Regensburg, Germany.
Edward K GeisslerDepartment of Surgery, University Hospital Regensburg, Regensburg, Germany.
Sebastian HaferkampDepartment of Dermatology, University Hospital Regensburg, Regensburg, Germany.
James A HutchinsonDepartment of Surgery, University Hospital Regensburg, Regensburg, Germany.
Katharina KronenbergDepartment of Surgery, University Hospital Regensburg, Regensburg, Germany.
University Hospital Regensburg · DEUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of advanced melanoma with combined immune checkpoint inhibitor (ICI) therapy is complicated in up to 50% of cases by immune-related adverse events (irAE) that commonly include hepatitis, colitis and skin reactions. We previously reported that pre-therapy expansion of cytomegalovirus (CMV)-reactive CD4

Indexed as

AdultAgedAged, 80 and overCD4-Positive T-LymphocytesFemaleFlow CytometryHumansImmune Checkpoint InhibitorsMaleMelanomaMemory T CellsMiddle AgedSeasonsImmune Checkpoint Inhibitorsassay validationbiomarkereffector memory T cellsflow cytometryimmune checkpoint inhibitionimmune-related adverse eventsmonocytesprediction

Identifiers

PMID34868015
PMCPMC8637156
OpenAlexW3214139613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.