Evidence map›Paper›PMID 34867990›Full record

ArticleFrontiers in immunology2021

Impairment of Multiple Mitochondrial Energy Metabolism Pathways in the Heart of Chagas Disease Cardiomyopathy Patients.

Priscila Camillo Teixeira, Axel Ducret, Hanno Langen, Everson Nogoceke, Ronaldo Honorato Barros Santos, João Paulo Silva Nunes, Luiz Benvenuti, Debora Levy, Sergio Paulo Bydlowski, Edimar Alcides Bocchi and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Alterations in Cardiac Metabolism byACS infectious diseases · 2025
    Article
  2. Review
  3. Interferon gamma signaling drives cardiac metabolic rewiring.bioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. DIGE Analysis of Clinical Specimens.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  14. Review
  15. Sex Differences in Cardiac Pathology of SARS-CoV2 Infected andFrontiers in cardiovascular medicine · 2022
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Priscila Camillo TeixeiraLaboratory of Immunology, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Axel DucretRoche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.
Hanno LangenRoche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.
Everson NogocekeRoche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.
Ronaldo Honorato Barros SantosDivision of Surgery, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
João Paulo Silva NunesLaboratory of Immunology, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Luiz BenvenutiAnatomical Pathology Division, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Debora LevyLaboratory of Immunology, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Sergio Paulo BydlowskiLaboratory of Immunology, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Edimar Alcides BocchiHeart Failure Team, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Andréia Kuramoto TakaraLaboratory of Immunology, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Alfredo Inácio FiorelliDivision of Surgery, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
Noedir Antonio StolfDivision of Surgery, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
Pablo PomeranzeffDivision of Surgery, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
Christophe ChevillardINSERM, UMR_1090, Aix Marseille Université, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa, Marseille, France.
Jorge KalilLaboratory of Immunology, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Edecio Cunha-NetoLaboratory of Immunology, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade de São Paulo · BRRoche (Switzerland) · CHInserm · FRTheories and Approaches of Genomic Complexity · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease cardiomyopathy (CCC) is an inflammatory dilated cardiomyopathy occurring in 30% of the 6 million infected with the protozoan

Indexed as

AdolescentAdultChagas CardiomyopathyEnergy MetabolismFemaleHeartHumansMaleMiddle AgedMitochondriaMyocardiumYoung Adultchronic Chagas disease cardiomyopathyenergy metabolismidiopathic dilated cardiomyopathyinterferon-gammaischemic cardiomyopathymitochondriaproteomicstwo-dimensional electrophoresis with fluorescent labeling

Identifiers

PMID34867990
PMCPMC8633876
OpenAlexW3213752312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.