Evidence map›Paper›PMID 34867975›Full record

ArticleFrontiers in immunology2021

Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases.

Javier Castillo-Olivares, David A Wells, Matteo Ferrari, Andrew C Y Chan, Peter Smith, Angalee Nadesalingam, Minna Paloniemi, George W Carnell, Luis Ohlendorf, Diego Cantoni and 18 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Treatment with Sulodexide Downregulates Biomarkers for Endothelial Dysfunction in Convalescent COVID-19 Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 9 institutions in 2 countries.

Javier Castillo-OlivaresLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
David A WellsLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Matteo FerrariLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Andrew C Y ChanLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Peter SmithLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Angalee NadesalingamLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Minna PaloniemiLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
George W CarnellLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Luis OhlendorfLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Diego CantoniViral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham, United Kingdom.
Martin Mayora-NetoViral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham, United Kingdom.
Phil PalmerLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Paul TonksLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Nigel J TempertonViral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham, United Kingdom.
David PeterhoffInstitute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
Patrick NeckermannInstitute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
Ralf WagnerInstitute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
Rainer DoffingerDepartment of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Sarah KempsterDivision of Virology, National Institute for Biological Standards and Control, Potters Bar, United Kingdom.
Ashley D OtterUK Health Security Agency, Porton Down, United Kingdom.
Amanda SemperUK Health Security Agency, Porton Down, United Kingdom.
Tim BrooksUK Health Security Agency, Porton Down, United Kingdom.
Anna AlbeckaMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Leo C JamesMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Mark PageDivision of Virology, National Institute for Biological Standards and Control, Potters Bar, United Kingdom.
Wilhelm SchwaebleComplement Laboratory, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Helen BaxendaleRoyal Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom.
Jonathan L HeeneyLab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
University of Cambridge · GBMedway School of Pharmacy · GBUK Health Security AgencyInstitute of Medical Microbiology and Hygiene · DEMRC Laboratory of Molecular Biology · GBNational Institute for Biological Standards and Control · GBAddenbrooke's Hospital · GBPapworth Hospital NHS Foundation Trust · GBUniversity of Regensburg · DE

Funding

Medical Research Council MC_PC_20016Medical Research Council MC_U105181010Wellcome Trust 200594/Z/16/Z
6 · The paper itself

Abstract

Precision monitoring of antibody responses during the COVID-19 pandemic is increasingly important during large scale vaccine rollout and rise in prevalence of

Indexed as

ConvalescenceImmunity, HumoralAntibodies, NeutralizingAntibodies, ViralAntigens, ViralBiomarkersCalibrationCOVID-19COVID-19 Serological TestingHumansImmunoglobulin IsotypesReference StandardsSARS-CoV-2Severity of Illness IndexAntibodies, NeutralizingAntibodies, ViralAntigens, ViralBiomarkersImmunoglobulin IsotypesAntibodiesCorrelates of ProtectionCOVID-19COVID-19 immune responseSARS-CoV-2Serological biomarkersWHO International Standard

Identifiers

PMID34867975
PMCPMC8640495
OpenAlexW3215000916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.