Evidence map›Paper›PMID 34867364›Full record

ArticleFrontiers in pharmacology2021

Dose Optimization of Aditoprim-Sulfamethoxazole Combinations Against

Muhammad Kashif Maan, Tamoor Hamid Chaudhry, Adeel Sattar, Muhammad Abu Bakr Shabbir, Saeed Ahmed, Kun Mi, Waqas Ahmed, Shuyu Xie, Li Xin, Lingli Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Muhammad Kashif MaanNational Reference Laboratory of Veterinary Drug Residues/MAO Key Laboratory for the Detection of Veterinary Drug Residues, Wuhan, China.
Tamoor Hamid ChaudhryPublic Health Laboratory Division, National Institute of Health, Islamabad, Pakistan.
Adeel SattarDepartment of Pharmacology and Toxicology, Faculty of Biosciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Muhammad Abu Bakr ShabbirDepartment of Microbiology, Faculty of Veterinary Medicine, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Saeed AhmedDepartment of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan.
Kun MiNational Reference Laboratory of Veterinary Drug Residues/MAO Key Laboratory for the Detection of Veterinary Drug Residues, Wuhan, China.
Waqas AhmedDepartment of Biomedical and Diagnostic Science, University of Tennessee, Knoxville, TN, United States.
Shuyu XieNational Reference Laboratory of Veterinary Drug Residues/MAO Key Laboratory for the Detection of Veterinary Drug Residues, Wuhan, China.
Li XinNational Reference Laboratory of Veterinary Drug Residues/MAO Key Laboratory for the Detection of Veterinary Drug Residues, Wuhan, China.
Lingli HuangNational Reference Laboratory of Veterinary Drug Residues/MAO Key Laboratory for the Detection of Veterinary Drug Residues, Wuhan, China.
University of Veterinary and Animal Sciences · PKHuazhong Agricultural University · CNNational Institute of Health · PKNational University of Medical Sciences · PKUniversity of Tennessee at Knoxville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combinations of two and more drugs with different target sites are being used as a new treatment regimen for resistant clones of bacteria. Though, achieving the right combination of the drugs for optimal dosage regimen is challenging. In our study, we studied the antimicrobial effect of aditoprim, a novel dihydrofolate reductase inhibitor, and its synergistic effect with sulfamethoxazole. Synergy testing was performed by checkerboard micro dilution method and validation of different checkerboard ratios by static and dynamic time-kill analysis and

Indexed as

aditorpimcombination therapyPK/PD modelingsemi-mechanistic PK/PD modeling 3sulfamethoxazole resistanceTrueperella pyogenes

Identifiers

PMID34867364
PMCPMC8635024
OpenAlexW3211659996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.