Evidence map›Paper›PMID 34867322›Full record

ArticleFrontiers in pharmacology2021

Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids.

Nadine Hellmuth, Camilla Brat, Omar Awad, Sven George, Astrid Kahnt, Tom Bauer, Hai Phong Huynh Phuoc, Dieter Steinhilber, Carlo Angioni, Mohamed Hassan and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Nitro Fatty Acids (NOMolecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Nadine HellmuthDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.
Camilla BratDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.
Omar AwadDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.
Sven GeorgeInstitute of Pharmaceutical Chemistry, Goethe-University, Frankfurt, Germany.
Astrid KahntInstitute of Pharmaceutical Chemistry, Goethe-University, Frankfurt, Germany.
Tom BauerPaul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines, Langen, Germany.
Hai Phong Huynh PhuocPaul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines, Langen, Germany.
Dieter SteinhilberInstitute of Pharmaceutical Chemistry, Goethe-University, Frankfurt, Germany.
Carlo AngioniPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University, Frankfurt, Germany.
Mohamed HassanDepartment of Chemistry, TU Kaiserslautern, Kaiserslautern, Germany.
Katharina J HockDepartment of Chemistry, TU Kaiserslautern, Kaiserslautern, Germany.
Georg ManolikakesDepartment of Chemistry, TU Kaiserslautern, Kaiserslautern, Germany.
Kai ZacharowskiDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.
Jessica RoosDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.
Thorsten J MaierDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.
Goethe University Frankfurt · DEUniversity Hospital Frankfurt · DEPaul Ehrlich Institut · DEUniversity of Kaiserslautern · DEAswan University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endogenous nitro-fatty acids (NFA) are potent electrophilic lipid mediators that exert biological effects

Indexed as

cyclooxygenase-2michael acceptorNF-κBnitroalkeneNrf-2, 5-lipoxygenasesoluble epoxide hydrolasestructure-function

Identifiers

PMID34867322
PMCPMC8637440
OpenAlexW3213698165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.