Evidence map›Paper›PMID 34867277›Full record

ArticleFrontiers in aging neuroscience2021

Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study.

Samantha L Gardener, Stephanie R Rainey-Smith, Victor L Villemagne, Jurgen Fripp, Vincent Doré, Pierrick Bourgeat, Kevin Taddei, Christopher Fowler, Colin L Masters, Paul Maruff and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Observational
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  3. Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction.International journal of environmental research and public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Samantha L GardenerCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Stephanie R Rainey-SmithCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Victor L VillemagneDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Jurgen FrippCSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, QLD, Australia.
Vincent DoréCSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, QLD, Australia.
Pierrick BourgeatCSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, QLD, Australia.
Kevin TaddeiCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Christopher FowlerThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Colin L MastersThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Paul MaruffThe Florey Institute, The University of Melbourne, Parkville, VIC, Australia.
Christopher C RoweDepartment of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, VIC, Australia.
David AmesNational Ageing Research Institute, Parkville, VIC, Australia.
Ralph N MartinsCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
AIBL Investigators
Australian Alzheimer’s Research Foundation · AUUniversity of Melbourne · AUAustin Health · AUAustralian e-Health Research Centre · AUUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AIBLAlzheimer’s diseaseAustralian Imaging Biomarkers and Lifestyle flagship study of ageingAβ-amyloidcaffeinecoffeecognitive declinedementia

Identifiers

PMID34867277
PMCPMC8641656
OpenAlexW3217299719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.