ReviewFrontiers in systems neuroscience2021
Cortical Hub for Flavor Sensation in Rodents.
Review in Frontiers in systems neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Targeting Neuroinflammation in the Piriform Cortex-Amygdala: Enhanced Efficacy of Niosome-Based Sodium Butyrate in Ischemic Stroke.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
- Myeloarchitecture, intra- and interhemispheric and thalamocortical connections of area 3b representing the teeth and tongue in galagos.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mapping Fos-immunoreactive neurons activated by intra-oral infusion of quinine, sucrose or water throughout the brain of B6 mice.Brain structure & function · 2026Article
- Effect of Phenolic Compounds and Terpenes on the Flavour and Functionality of Plant-Based Foods.Nutrients · 2025Review
- Cortical coding of gustatory and thermal signals in active licking mice.The Journal of physiology · 2025Article
- Cortical Coding of Gustatory and Thermal Signals in Active Licking Mice.bioRxiv : the preprint server for biology · 2024Article
- Multisensory Integration Underlies the Distinct Representation of Odor-Taste Mixtures in the Gustatory Cortex of Behaving Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The role of the mediodorsal thalamus in chemosensory preference and consummatory behavior in rats.Chemical senses · 2024Article
- Glucagon-Like Peptide-1 Receptors in the Gustatory Cortex Influence Food Intake.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Oral thermal processing in the gustatory cortex of awake mice.Chemical senses · 2023Article
- Active Licking Shapes Cortical Taste Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Review
- The role of viscosity in flavor preference: plasticity and interactions with taste.Chemical senses · 2022Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The experience of eating is inherently multimodal, combining intraoral gustatory, olfactory, and somatosensory signals into a single percept called flavor. As foods and beverages enter the mouth, movements associated with chewing and swallowing activate somatosensory receptors in the oral cavity, dissolve tastants in the saliva to activate taste receptors, and release volatile odorant molecules to retronasally activate olfactory receptors in the nasal epithelium. Human studies indicate that sensory cortical areas are important for intraoral multimodal processing, yet their circuit-level mechanisms remain unclear. Animal models allow for detailed analyses of neural circuits due to the large number of molecular tools available for tracing and neuronal manipulations. In this review, we concentrate on the anatomical and neurophysiological evidence from rodent models toward a better understanding of the circuit-level mechanisms underlying the cortical processing of flavor. While more work is needed, the emerging view pertaining to the multimodal processing of food and beverages is that the piriform, gustatory, and somatosensory cortical regions do not function solely as independent areas. Rather they act as an intraoral cortical hub, simultaneously receiving and processing multimodal sensory information from the mouth to produce the rich and complex flavor experience that guides consummatory behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.