ArticleFrontiers in cellular neuroscience2021
Ir76b is a Co-receptor for Amine Responses in
Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 48 citations in OpenAlex.
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- Identification of candidate chemosensory receptors based on transcriptome analysis in the monophagous insect Protegira songi (Lepidoptera, Noctuidae).BMC genomics · 2026Article
- Multilayer regulation underlies the functional precision and evolutionary potential of the olfactory system.Nature communications · 2025Article
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- The sensory arsenal mosquitoes use to find us.Trends in parasitology · 2025Review
- Alternative strategies based on transgenic Drosophila melanogaster for the functional characterization of insect Ionotropic Receptors.Biological research · 2025Article
- An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system.EMBO reports · 2025Article
- Impact of elevated COScientific reports · 2025Article
- Functional characterization and evolution of olfactory responses in coeloconic sensilla of the global fruit pest Drosophila suzukii.BMC biology · 2025Article
- An integrated anatomical, functional and evolutionary view of thebioRxiv : the preprint server for biology · 2025Article
- CRISPR/Cas9-Based Genome Editing of Fall Armyworm (Biomolecules · 2024Review
- Orco-dependent survival of odorant receptor neurons in ants.Science advances · 2024Article
- An expanded neurogenetic toolkit to decode olfaction in the African malaria mosquito Anopheles gambiae.Cell reports methods · 2024Article
- Females smell differently: characteristics and significance of the most common olfactory sensilla of female silkmoths.Proceedings. Biological sciences · 2024Article
- Odorant receptor co-receptors affect expression of tuning receptors inFrontiers in cellular neuroscience · 2024Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Two large families of olfactory receptors, the Odorant Receptors (ORs) and Ionotropic Receptors (IRs), mediate responses to most odors in the insect olfactory system. Individual odorant binding "tuning" OrX receptors are expressed by olfactory neurons in basiconic and trichoid sensilla and require the co-receptor Orco. The situation for IRs is more complex. Different tuning IrX receptors are expressed by olfactory neurons in coeloconic sensilla and rely on either the Ir25a or Ir8a co-receptors; some evidence suggests that Ir76b may also act as a co-receptor, but its function has not been systematically examined. Surprisingly, recent data indicate that nearly all coeloconic olfactory neurons co-express Ir25a, Ir8a, and Ir76b. Here, we demonstrate that Ir76b and Ir25a function together in all amine-sensing olfactory receptor neurons. In most neurons, loss of either co-receptor abolishes amine responses. In contrast, amine responses persist in the absence of Ir76b or Ir25a in ac1 sensilla but are lost in a double mutant. We show that responses mediated by acid-sensing neurons do not require Ir76b, despite their expression of this co-receptor. Our study also demonstrates that one population of coeloconic olfactory neurons exhibits Ir76b/Ir25a-dependent and Orco-dependent responses to distinct odorants. Together, our data establish the role of Ir76b as a
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